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Lymph Node with Reactive Hyperplasia-Help?
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Lymph Node with Reactive Hyperplasia-Help?

I had a large Core needle biopsy done 2 weeks prior to surgery to my breast surgery for DCIS with a focus of less than 1mm of microinvasion, & a sentinel node was taken out for examination.
What does the information below mean.

My pathology report stated: Sentinel Node #1, Excisional Biopsy:
Touch Preparation Smear: No Malignant Cells Seen.
H&E Sections: One Lymph Node with Reactive Hyperplasia: No evidence of Metastiatic Carcinoma.
Cytokeratin Immunostain: No Evidence of Metastatic Carcinoma.

What is Reactive Hyperplasia? What causes it? Is this common?


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2 Comments
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Avatar m tn
Hi there.

Reactive hyperplasia is a response of the lymph node to foreign antigens especially during infection or in cases of microinvasive disease from a DCIS.  The good news is that there are no malignant cells seen in the lymph node.  This is no cause for alarm but I still suggest that you have regular follow ups with your doctors or surgeon.  I would also suggest to discuss with your doctors regarding additional radiation therapy for your DCIS.  Check your breasts regularly from now on.  Regards and God bless.
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Avatar f tn
Thank you for your prompt response to my question regarding Reactive Hyperplasia in the lymph node. I don't understand what the following statment means in your response "in cases of microinvasive disease from DCIS".  Should I be concerned with this even though there was no cancer detected in the node? Yes, I will be doing radiation (not chemo) and will have regular follow up visits with my doctors.  Thank You for your advice and if you can please clarify your response.
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