I have MS and arachnoiditis, a disease of the nerves in the brain and spine. I have been on zoloft for almost 20 yrs, have tried several other anti-depressants in the past but always come back to Zoloft. My physician has suggested effexor which I tried and it helped with my nerve pain, but made me a little "nuts". Now my new doc wants to add a norepinefrin to my or something else since my siutation healthwise is so despairing at times....plus with Zoloft, weight loss is almost impossible, which would help my health issues. My doc says at times when someone has been on Zoloft for so long the brain quits making the serotonin needed. I am on a morphine pump and that also does not help in the depession department . I have two children still at home, and one is a paraplegic.....I need to be able to function, even though I know my limitations, I do not want to be depressed esp, for my family