One day missing Zoloft shouldn't make that much difference. Plus if you kept at your normal dose afterwards you should be back to normal before now anyway.
The protonix is another story though,since stomach issues are unpredictable. Your stomach could have been on the edge of giving you trouble and missing the med could set it off,or it just might have decided to act up on its own anyway. Best of luck dealing with it - been there wondering if the pain would ever be manageable for about 5 years, then it disappeared for some reason.
People are different, but yes, a skipped dose does bring withdrawal symptoms for many people. Other than Prozac, ssris don't stay in the body very long, which is one of the reasons many believe Prozac has fewer withdrawal problems. That would explain the spaciness. After years of being on clonazepam, if I miss my dose by even an hour of when I regularly take it I can start feeling really weird. While that's a benzo and not an antidepressant, if you're going to take these pills that have withdrawal problems just try hard to stick to your schedule. But the stomach problems aren't the ones you'd expect from Zoloft- that would be more likely to be diarrhea or something like that. What you've got is probably caused by taking the protonix on a regular basis. These meds suppress stomach acid, but the stomach must produce that acid in order to digest minerals and protein. So when you take those kinds of drugs on a regular basis, the stomach has to produce more and more acid to compensate. That's why digestive problems are usually best treated by someone other than a doctor, who only knows how to suppress things, not fix them. Digestive problems are usually from dietary problems or insufficient chewing or eating too soon before going to bed or a lack of exercise that helps keep things moving. There are a lot of natural medicines that help with this until you find a solution that don't interfere with the regular functioning of the stomach. Of course, the same applies to your Zoloft -- keep looking for a cure through therapy or something else, because the drug just alters your body so you don't feel so bad, it doesn't fix the underlying problem. Often nothing else works, which was the case with me, but don't stop trying. You never know. With my digestive problems, and they are rampant with people on antidepressants and anxiety sufferers, drugs just made the problem stick around and need to be treated. The best treatment I got was a doctor who told me to start TM, and that got rid of my biggest problem, which was developing an ulcer in my twenties. Now I treat these things with aloe vera juice and DGL and peppermint oil caps, when needed, because that doesn't permanently push my stomach into imbalance.