If you're saying the Effexor was working well for your depression but isn't anymore, it may be it's tapped out -- these drugs do poop out on many people. The only solution for that is to change meds. (if you do that, do it very slowly, as slowly as you need to). Now, you're taking one stimulating med (Effexor, which increases adrenaline and for that reason can increase anxiety), one sometimes sedating and sometimes stimulating med (Lexapro, which is a low dose and has to be because you're now taking two meds that target serotonin which can be dangerous) and two downers -- ambien and Ativan. So of course you're going to lose energy from when Effexor was working because Effexor is artificially stimulating. Can't tell you where to go from here, but if your main drug has tapped out, you just have to move on. Talk to your psychiatrist about that.