I'm currently on 300 bupropion, along with topamax 100 and still have had no weight losse. I just started the 300 bupropion after being on 150 last week and have already had crying spells but this was the week of my period so I was thinking I just could be "emotional". Before I was on Zoloft 25-150 bupropion but I ate to much on it, I'm hoping for weight loss but every antidepressant I take makes me eat what to do I do??