I started Sertraline (Zoloft generic) 6 days ago. I am still testing at a low 25 mg dose. I think I had/have an increase in fatigue, a side effect and can not say I feel any "better". Happily, no serious side effects but the fatigue is also present due to bereavement/grief struggle and that may the main driver for fatigue, Sertraline may eventually reduce that depression-type symptom, fatigue.
Welcome any experience on how long it took to notice: 1) benefit, 2) decrease in side effects.
Yes, I can search the web but look form the personal touch of a living patient telling of their experience.