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I haven't experienced any abnormal weight loss or gain. I wasn't eating when I started taking it, so of course I gained a little weight when I started eating again, but nothing more than five or ten pounds, which I easily lost while still medicated.
The side effects I experienced during the first couple of weeks were dizziness/light-headedness, fatigue, nausia, digestive abnormality (constipation/diarrhea), and just feeling really icky (ha, sorry, there's no other way to describe it). Pretty much the same side effects reoccur once you start tapering off (when your doctor tells you to).
Please, if you are taking it, or are considering taking it, don't stop all at once. If you think you will have some sort of complication where you can't take it any more, tell your doctor and have him/her give you tapering instructions. The side effects of stopping cold turkey are horrible and withdrawal is not something you want to go through and it often causes a relapse and has been linked to increased depression and thoughts of suicide. Some people actually get "shocks" where it feels like they are being electrocuted, and can hear zapping sounds. It is definitely worth the extra money just to refill your prescription for tapering purposes instead of quitting.
I think 1 to 5 years would be the normal amount of time, definitely no less that 6 months. I don't know anyone who took it for more than a couple of years. You definitely want to work on whatever it is that is making you need to take zoloft and find alternative solutions (therapy/journaling/exercising/stress coping routines). Also a lot of fruits and other natural sources have serotonin in them (the chemical that makes zoloft work.. pretty much) like tomatoes and bananas, so you can research which foods you can eat to help you out if you need that little extra boost once you are off meds. Wikipedia.com is helpful and also google search different stress relief exercises if anxiety is a problem for you.