Can switching ssri cause it not to work

[Keri70]

Hi. I was on zoloft  50 mgs when I was 35. It worked great. I was on it for 6 months. Then went off. Then 10 years later I got a relapse anxiety and a friend told me about paxil. I stayed on it for 10 years. After gaining 40 lbs my dr suggested I go to zoloft. It worked for 2 years. Then it stopped. I was switched to lexipro. Worked fine for 1 year and got the symptoms back upping to 20 mgs did nothing. Now back on zoloft for 6 weeks 200 mgs  I am starting to feel better. My question is a friend told me recently that years ago I should not have switched to paxil and went to zoloft and perhaps I would not  have encountered some of these relapses.

[lesweet1971]

My friend went from years on Paxil to Zoloft with no problems. Depression & anxiety often re occur in our life. Some of us are just prone to it. You did nothing wrong switching meds/trying others.

I took prozac in college and it worked like a charm. 15 yrs later I had another bout of anxiety and depression and tried it again and it did nothing sadly. Sometimes I wonder abt generic vs brand name bc in college Prizac was brand name and when I tried it 15 yrs later, it had gone generic and the generic didn't work.

Don't worry, you did nothing wrong. Sending healing thoughts your way!

[Bubulous]

I have no experience with pail but I take Zoloft and it work well for me.