I've tried typical PMS meds with both acetaminophen and ibuprofen in them but they don't help enough. I also take evening primrose oil and that has helped with breast tenderness at least. There have been times when I get such intense itching aching spots in the muscles of my arms and legs that I've resorted to applying ice packs to numb the sensations. It feels like my insides have been rubbed with stinging nettle. It does help but it's not always convenient and of course the relief is short-lived. I'm wondering if its hormone related inflammation at that time in my cycle or something else like over-activity in the nerve endings. The only good thing about it is that it's time-limited.