DERMATOLOGY COMMUNITY
Melanocyte cell life

Melanocyte cell life

Hello, I was wondering how long the average human melanocyte lives in the skin... I know there are ~1000-2000 per sq mm (Wikipedia); if you were to some how increase this to ~4000 for example (chemically) would the number decrease over time back to 'normal' or would the ~4000 divide (and die) at a rate to maintain ~4000 cell density?  Thank you for your time and help.
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4 Comments Post a Comment
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Avatar_m_tn
Cell death or Apoptosis as is known is a programmed one,and I presume body would seek a balance by destroying a few.
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Avatar_m_tn
But then if you can increase the no and quantity of melanin granules ,yes they can get retained.
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Avatar_n_tn
Is there any data on how long the lifespan of a melanocyte is?

Also, in regards to the melanin granules, are they like cells containing melanin and the melanin 'deteriorates' over time (as a person gets less tan) or do the granules slough off with other skin cells and they are lost to the body... do they build throughout a persons life, promoting faster tanning?
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Avatar_m_tn
The number of melanocytes in all races is constant.They are derived from the neural cells.The colour of melanocytic granules,and their no and distribution determine the color.These granules are donated to our skin cells known as keratinocytes.As we grow older the melanocytes reduce production and thus is the so called grey hair which is the true color of keratin.If the cell incorporates more melanin you get the tan,even rearrangement of the granules are good enough.
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