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What can cause liver enlargement?

Dear Dr,
10 days ago I was at my swimming class after work and felt a pain on my upper right abdomen. The day before, I noticed that my belly was swollen and I was felling pain in that area. As I couldn't identitify where the pain came from, I went to a hospital near my job and ask a doctor. He asked for a US. The result of the US is "hepatomegalia". As I'm under treatment for depression and have to take lots of medicines, I called my doctor for instructios. She doesn't think that there is a relationship with all this things and said that the liver doesn't pain. As the pain was still bothering me, I went to see a gastrodoctor. She said the pain is in fact in the liver and asked for lab tests for hepatitis (A,B,C) and liver function. She said that my liver is "very grown" and "painfull". The lab tests are all negative and the only finding is a high hemosedimentation rate. I'm following the instructions for rest these days. I want ask you this: if I don't have any kind of hepatitis, what could be the cause of this pain and enlargement? Is there a possible link between muscle weakness and this liver enlargement? Drugs to treat depression (reboxetine+paroxetine+valproic acid) can cause liver enlargement? What should be the next appropriate step after the lab tests?
Thank you very much for your attention (sorry for any English mistake)
Helen
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Avatar universal
hi all, i was at the dr. 5 trs ago they told me my liver enzymes where high, I thought nothing of it he gave me a ultra sound it was fine . now last week i was at the dr. so i said to do another blood test to see if the enzymes came down so he did and they are still high they came back a 113 he said they should be 0to 42 so now i go to a specialist to talk i have 2 kids i need some help figuring this out. thak you !
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Avatar universal
Hi my name is Vicki and on Thanksgiving of 2000 I was having some pain in my stomach and I was real dizzy and I almost fainted. About three years ago I tried to give blood to my sister when she was in the hospital and a few weeks later I got a note in the mail saying that they could not use my blood because my liver and my thyroids were elevated. So that day I went to the doctor and told them about it. They put my liver of and said that it was fine there wasnt any thing wrong with it and my thyroids they put me on sinthriodand about five or six monthes being on that they webt back to normal. And at that time they did tell my that they thought that maybe my birth-control was the cause of my liver going up. So for four and a half years I havent had any thing. I just had my second baby and I thought that I would get back on birth-control and then I started having this dizziness and fainty, nauses, vomiting and shaking all of the time . So when I went to the doctor in November they tested my liver again and this time it was coming up as 109 and I know that it is suppose to be coming up as 31. At that time my doctor scared me because she had said that she thought that I had liver disease. Now at that time it was right before Christmas. I have two kids and I am 25 and I didnt know what I was going to do.So they continued running test. I have had an ultra sound done and it came back negative that every thing was fine. At that time my regular doctor didnt know any thing else to do so she sent me to a specialist. I went to the specialist and they told me that they thought that I had gallstones in my gall bladder so they had a CT Scan done and just yesterday I got a EGD where they go down your throat to see if you have ulcers in your stomach well I didn't and they found out that I have a fatty liver they are running some sort of blood test and if it comes back positive  they are going to run a liver biopsy. Now the did run test to see if I have hepatities A B C and they all came back negative. If any one is having the same problem and have any advice to give me or what to do next please write me back .  And if there is any one that can tell me more about a fatty liver because they did put me on a low fat diet.           Thank you
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Avatar universal
I  am 20 and very  soon to be 21 and I went to the Docter and he is sending me for test because my liver is enlarged and I have very bad pain right under my rib cage on my right side The doc told me that in his 30 years of work he has seen only two women with this type of problem he stopped my birth control pills and said that this is a very very rare side effect from the pills if anyone can tell me more on this please e-mail at
***@**** I'm very scared i go for my test today
3-8-01 maybe nothing is wrong with me thats what i keep telling myself. I hope its nothing thank you for your help, Stacy
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Avatar universal
Eight years ago I came down with bad flu like symptoms that settled into chronic fatigue.  This was accompanied with sensitivity to many drugs and a sudden intolerance to alcohol. Other symptoms were experienced that are normally associated with chronic fatigue and some occasional twitching occurred.  The fatigue symptoms improved after about 18 months.  Some blood work was performed and the only significant result the doctor discussed with me was elevated active titers for Epstain Barr.

More recently I have been experiencing a bloated abdomin, increased fatigue, and occasionally what feels like a pounding heart.  I had my ALT-SGPT tested once a month for 4 months with normal Lab readings under 40 mine were in the 50s and 60s. Viral Hepititus tests were conducted with no sign indicated.  

Next I went to an internist and much bloodwork was done.  This included WBC, RBC, HGB, HCT, MCV, MCH, RDW, MCHC, Platelet, MPV, Neutro, Lymph, Mono, EOS, BASO, Neutrophil ABS, Lymph absolute, Mono Absolute, eosinophil ABS, Basophil ABS, RBC Morph, Protime, INR.  Of these Lymph% was marginal low at 19.8 with 20 to 46 normal.  Mono was 13.9 with 4 to 11 normal.  EOS was 5.1  with zero to 4 the normal range.  All the others fell into normal range.  

The chemistry tests were:
AST-SGOT.  ALT-SGPT, Alkaline Phosphatase, Bilirubin, total; Bilirubin, direct; Bilirubin, indirect;  Protein, Total serum; Albumin, serum; Globulin, Iron Serum, Iron Binding capacity, Saturation, Thyroid stimulating Hormo, and Ferritin.  Of these the ALT-SGPT level was moderately high at 55 and the globulin level was 2.3, while normal range should be 2.8 to 4.4.  The Ferritin level normally runs 24 to 340 while my level was at 653.

An abdominal sonogram was conducted and it showed increased echogenicity with decreased though transmission, consistent with diffuse fatty infiltration and/or cirrhosis.  No evidence of bile duct dilation was seen.  Intrahepatic lesions could not be ruled out due to the dense nature of the liver.  The common bile duct was not dilated.  

I am 50 pounds overweight and am a 45 year old pear shaped male.  I am scheduled for a liver biopsy on March 16.  My questions are what is the likely cause of the enlarged liver and test abnormalities?  Could this be something that started 8 years ago?  I have cut out all alcohol and aspartame.  I have not been a heavy drinker but have drank 2 quarts of diet pepsi for the last 15 years.  Thanks for any advice you can offer.
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Avatar universal
Cecilia ~
    If I were you, I would see a liver specialist. You need a contrast liver CT scan, and if that indicates a problem, a liver biopsy. I have very similiar symptons, and after these tests, found that I have NASH...non-alcholic sterotic hepatitus. It progresses to cirrhosis, which is where I am now. The liver certainly CAN have pain! You obviously have inflammation in yours, and there has to be a reason. Having dealt with this the last 2 years, I would highly recommend this. I hope and pray you find some help and relief.
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Avatar universal
I did not receive an answer Re: previous letter. Probably a mix up on my part.
     I have problem as follows. When I lay down for any period of time, 1 t0 2 hours, and also when I ge up in the morning , My stomach is swollen. This swelling is in front and imediately below my rib cage.
There is some pain, not extreme but I know it is there. After I am up and about for a hour or two the pain leaves alomg with most of the swelling. Also I am very short winded, any exertion hardly at all     or some times when I turn my shoulders extremely to left it gives me the it acuses shotness of breath.                              
     I had triple bypass two years ago and the operation went very well. I was mot able to participate in rehab because I have neuropathy from my knees to my toes and have to wear braces because of this condition

                     Awaitting your comments

                                      Fred
Helpful - 0

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