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What can cause liver enlargement?

Dear Dr,
10 days ago I was at my swimming class after work and felt a pain on my upper right abdomen. The day before, I noticed that my belly was swollen and I was felling pain in that area. As I couldn't identitify where the pain came from, I went to a hospital near my job and ask a doctor. He asked for a US. The result of the US is "hepatomegalia". As I'm under treatment for depression and have to take lots of medicines, I called my doctor for instructios. She doesn't think that there is a relationship with all this things and said that the liver doesn't pain. As the pain was still bothering me, I went to see a gastrodoctor. She said the pain is in fact in the liver and asked for lab tests for hepatitis (A,B,C) and liver function. She said that my liver is "very grown" and "painfull". The lab tests are all negative and the only finding is a high hemosedimentation rate. I'm following the instructions for rest these days. I want ask you this: if I don't have any kind of hepatitis, what could be the cause of this pain and enlargement? Is there a possible link between muscle weakness and this liver enlargement? Drugs to treat depression (reboxetine+paroxetine+valproic acid) can cause liver enlargement? What should be the next appropriate step after the lab tests?
Thank you very much for your attention (sorry for any English mistake)
Helen
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Avatar universal
Helen,
I am curious how you got on Reboxetine?  It has not been approved for use in the U.S., yet.  Do you live in the U.S. and are part of a clinical trial with Reboxetine?  Where, if that is the case?  I know several folks with intractable depression that are eagerly awaiting Reboxetine's approval.  Has it helped you?  As for your meds not causing liver dysfunction, I totally disagree.  One of the most common reasons for Valproic Acid being discontinued in therapy is elevated liver enzymes.  Valproic Acid IS hepatotoxic (toxic to the liver) and psychiatrists routinely monitor liver enzymes of their patients that are on Valproic Acid for at least one year after initiation of the drug.  Best of luck to you.
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