Factor V and Protein S deficiency

I have both Factor V mutation as well as a low Protein S deficiency.  I had a stroke with my first pregnancy and am now weighng the risks of possibly a 2nd pregnancy.  Has anyone been diagnosed with both Factor V  and Protein S deficiency and had a successful pregnancy?


This discussion is related to is it safe to have more children.

[Heather5]

Hi CMC! I'm so sorry to hear about your stroke. That must have been quite a scare...
I know there are a few women on here with different blood clotting issues; mostly MTHFR, but I've also seen a few posts about Factor V. Don't think I've read about anyone with both Factor V and Protein S Deficiency, though.

Personally, I have Factor V (one gene), and I'm now 23 weeks pregnant. I'm on baby aspirin and lovenox to help prevent any blood clotting complications. I've never had a blood clot before, but I've had two pregnancy losses, and I'm not taking any chances this time! Especially since we had to resort to IVF for this pregnancy. My two previous pregnancies were natural, but after my second loss in September 07, we just weren't getting pregnant again.

So when were you diagnosed with Factor V and Protein S? Was it after the stroke? If so, you might be able to use blood thinning medications (like lovenox) during a second pregnancy from the very beginning. I'm not really sure if having both Factor V and Protein S Deficiency would make things more complicated, though. I would probably start by setting up an appointment with your doctor, or even a specialist, to discuss your concerns.

Best of luck to you!