Yes, I had been on various different anti-depressants (Paxil, Zoloft, Wellbutrin) at different times in my early 20's to mid-20's as a result of "situational depression" (I was in a Domestic Violence marriage at the time.) The Effexor and then later, Wellbutrin (along w/ Ambien) was Rx'd after a BAAaaaaaad reaction to Prednisone. Each time I've been on anti-depressants, I've suffered pretty awful side-effects (Lucid nightmares and full-blown night terrors, cold sweats, worsening of the depression, suicidal thoughts that I'd not had prior to the meds, restless/agitation/panic/anxiety feelings, heart palpitations, the list goes on and on.) It is for this reason that I am seeking a homeopathic approach to my condition at this time.