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H. pylori treatment

My wife just had an endoscopy showing lesions in the stomach and intestinal metaplasia. It did not show presence of H. pylori. She takes Prilosec!

1) My understanding is that if a patient is taking a proton pump inhibitor like Prilosec the endoscopy will not reveal presence of H. pylori even if it is there. She should have stopped taking it 2 weeks before the endoscopy.  Is that correct?

2) She has asked for a breath (urea) test but her doctor has not given her one. Wouldn't that be useful? She has GERD and I don't know whether it would be harmful to stop taking Prilosec 2 weeks before the breath test.

3) I understand that once metaplasia has set in, even the eradication of H. pylori is less valuable.

4) Should she just assume --- if no breath test is given --- that H. pylori is present and ask for   amoxicillin/prilosec therapy? Problem is that after such treatment antibodies stay in the blood stream so you never know if the H. pylori has been eradicated, right?

If possible I would like a GI doctor to answer this one. Thank you.

By the way, my wife had metaplasia of the cervix and a D&C cured that one, but she does not want to have part of her stomach removed.

What sort of treatment would you recommend for a patient who has metaplasia and lesions in the stomach but the endoscopy showed no H. pylori? She takes Prilosec and sometimes Reglan.

If possible I would like a GI doctor to answer this one. Thank you.




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Avatar universal
My wife went thru two treatments of H. Pylori. After eradication the only reliable tests are the breath test or a biopsy for the first year following treatment. I can say for sure the any ant-acid shold not be taken for two weeks and anti-biotics should not be used for at least one month before the breath test. As for the free doctor comment, it says $16.00 question. I have a resent post (today). In studying the MD responses to GI questions the MD seems to regurgitate the same answer to multiple questions.

Good luck.
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Avatar universal
If you'd like to have a doc answer your question, you may want to post this over on the other gastro board which is monitored by a doc. It's a fee-based board.
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