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False negatives
Can Hypogammaglobulinemia cause false negative HIV antibody tests tests? There seems to be some disagreements within the medical community about this. Anyone know if this has been known to happen?
I have also read that only chemotherapy and organ transplant patients need worry about this.
Even if for some reason antibodies were not present due to immune deficiency, would the ANTIGEN portion of a 4th generation DUO test still be detectable?
I have also read that only chemotherapy and organ transplant patients need worry about this.
Even if for some reason antibodies were not present due to immune deficiency, would the ANTIGEN portion of a 4th generation DUO test still be detectable?
How is my advice not correct, this person has a condition that impairs the body ability to produce antibodies. If someone body can't produce antibodies then when infected with HIV it won't produce HIV antibodies. So nothing will show up on ELISA or Western Blot test.
Their are documented cases of people never testing positive on antibody test for HIV because of this condition, even years after infection. The whole problem with this condition is the inability to produce antibodies.
Their are documented cases of people never testing positive on antibody test for HIV because of this condition, even years after infection. The whole problem with this condition is the inability to produce antibodies.
You came here and also another forum asking about a non risk issue and now you are giving advice that is not correct.
Their are documented cases of people with CVID not ever producing detectable levels of HIV antibodies even years after infection. Their bodies just don't produce them. Any antibody test such as western blot would always give a false negative.
It depends on the severity of your CVID, People with severe CVID may not ever produce antibodies for HIV, and if you are taking antibody infusions then traditional HIV test are not appropriate for you. You should talk to your immunologist.
Your test is conclusive and no reason to think otherwise.
Only once, in 2000 for 4 weeks
Have you ever been hospitalized for you condition several times a year?
I also wanted to note a statement made by you that has added to my confusion and seems to contradicts the advise you have just offered me-
"Yes those that have an immosupressive disease my take longer than 3 months, but all will be detected by 6 months." (Teak)
"Yes those that have an immosupressive disease my take longer than 3 months, but all will be detected by 6 months." (Teak)
You have confused me Teak. In the expert column it is stated that; "It is the antibody that clears p24 out of the blood. In other words, the p24 cannot become negative until at least several days (typically a couple of weeks) after antibody appears" (Dr. Handsfield).
CDIV is a condition that affects antibody production. So how would P24 not be present if there had not yet been enough antibodies to clear P24?
You have also told me that I don't need to bother with a PCR test however there is evidence to suggest that antibodies due to CDIV may not be detectable, and you have just told me that ANTIGEN would not be present during my 5, 10, 12 week tests.
Can you please clarify for me?
CDIV is a condition that affects antibody production. So how would P24 not be present if there had not yet been enough antibodies to clear P24?
You have also told me that I don't need to bother with a PCR test however there is evidence to suggest that antibodies due to CDIV may not be detectable, and you have just told me that ANTIGEN would not be present during my 5, 10, 12 week tests.
Can you please clarify for me?
Antigens are detected from week 1 to week 4, not week 5, 10, or 12. If you are having trouble accepting your conclusive test result then I suggest you seek professional mental help.
Does anyone else have any input for me? I would love to accept my negative test result however I want to be certain that CVID would not interfere with results as I have seen some evidence that it does. Can anyone confirm that even if antibodies were not present in DUO testing, that ANTIGEN would have still been detectable at 5, 10, 12 weeks?
Thanks
Thanks
Accept your negative test result.
Thanks Teak.
I am aware that 12 weeks is considered conclusive by a majority of health authorities - hence the reason I was so happy with my 12 week Duo negative.
My concern is that many of these same authorities, including the CDC state that "False non-reactive (negative) test results may be obtained from clients with Hypogammaglobulinemia conditions."
I am aware that 12 weeks is considered conclusive by a majority of health authorities - hence the reason I was so happy with my 12 week Duo negative.
My concern is that many of these same authorities, including the CDC state that "False non-reactive (negative) test results may be obtained from clients with Hypogammaglobulinemia conditions."
You have conclusively tested negative at 12 weeks.
Thanks Teak. So you do not believe it is necessary to take a PCR/RNA test to verify with my potential lack of adequate antibodies for detection? Assuming you mean that the Antigen portion of DUO be sufficient?
Thanks
Thanks
It won't affect your test results.
I had several non protected heterosexual sex exposures and had HIV DUO testing at 5, 10, 12 weeks negative from last exposure.
My concern is due to CVID as I was not aware that this could potentially effect my test results.
My concern is due to CVID as I was not aware that this could potentially effect my test results.
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