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How to make Hbsag negative?
How to make Hbsag negative?
Is there any cure or any medicine to make Hbsag negative?
I was tested medically four years before for a job and found hepatitis B positive.Then I consulted a doctor,he took my complete hepatits tests and told me nothing to worry because hepatitits b virus was non-reactive.But when tested medically it shows positive.
I am much confused because this HbsAg positve is really doing problems for my jobs and career. Please guide me what to do and how can I get rid of this HbsAg??
Is there any cure or any medicine to make Hbsag negative?
I was tested medically four years before for a job and found hepatitis B positive.Then I consulted a doctor,he took my complete hepatits tests and told me nothing to worry because hepatitits b virus was non-reactive.But when tested medically it shows positive.
I am much confused because this HbsAg positve is really doing problems for my jobs and career. Please guide me what to do and how can I get rid of this HbsAg??
Just a little busy right now, but i will try to pm.
Re naps treatment, the infusion method makes it very expensive and quite difficult to apply. Only hospitals and special doctors would be able to provide the infusions, thuse it is hard to apply this on a larger scale.
Re naps treatment, the infusion method makes it very expensive and quite difficult to apply. Only hospitals and special doctors would be able to provide the infusions, thuse it is hard to apply this on a larger scale.
I dont know but I have been given hints that im on TAF (I have a feeling I am on TAF) As Daxa scan shows no effect on bones my numbers have been pretty good if you could please send me a private message so I would be very happy to show you them :)
Re NAPS
Surely as a patient who cares about the delivery method long as it provides HBSAG loss and sustained surface anti body production no?
Re NAPS
Surely as a patient who cares about the delivery method long as it provides HBSAG loss and sustained surface anti body production no?
That's a good news at least the Gilead 'll facilitate the drug to the market. Thanks studyforhope
You don't know if you are receiving TDF or TAF.
There are probably some talks between Gilead and replicor. The fact that the naps need weekly infusions does not make it an easily marketable item, so it might be a tough sell.
There are probably some talks between Gilead and replicor. The fact that the naps need weekly infusions does not make it an easily marketable item, so it might be a tough sell.
Im on a TAF trial.
It seems ok but i wouldnt say its setting the world on fire you know.
I thought I heard before that Gilead expressed an interest in buying NAPS from replicor no?
It seems ok but i wouldnt say its setting the world on fire you know.
I thought I heard before that Gilead expressed an interest in buying NAPS from replicor no?
The reasons vary.
The gs9620, the toll like seven activator molecule, gave good results in a woodchuck study and then decent results in a small chimp study. In humans the current two year running study seems to have produced just some results with activation markers, but nothing worth presenting in terms of dna or hbsag reduction.
The tarmogen study, a therapeutic vaccine using multiple HBV TCELL epitopes fortified in a yeast antigen, was recently reported to have no meaningful results. There were big hopes in the concept, but the expected mechanisms apparantly did not work.
Gilead is also active in a tenofovir Pegasys combo study, but I see no reason why it would turn out any different than the already reported rather large studies with this combo. Please note that the old easl press release is somewhat misleading and not informative enough in the details on patient numbers and their pretreatment conditions.
The only development that is to my knowledge promising at this point in time with Gilead is the new tenofovir alafenamide trial, that will lead to approval and availability in 2017 or 18. This is still a clear step forward, since at least the bothersome kidney toxicity will then be a thing of the past. It is unclear at this time if the muscle and heart mitochondrial inhibition will also be less with the new compound.
The gs9620, the toll like seven activator molecule, gave good results in a woodchuck study and then decent results in a small chimp study. In humans the current two year running study seems to have produced just some results with activation markers, but nothing worth presenting in terms of dna or hbsag reduction.
The tarmogen study, a therapeutic vaccine using multiple HBV TCELL epitopes fortified in a yeast antigen, was recently reported to have no meaningful results. There were big hopes in the concept, but the expected mechanisms apparantly did not work.
Gilead is also active in a tenofovir Pegasys combo study, but I see no reason why it would turn out any different than the already reported rather large studies with this combo. Please note that the old easl press release is somewhat misleading and not informative enough in the details on patient numbers and their pretreatment conditions.
The only development that is to my knowledge promising at this point in time with Gilead is the new tenofovir alafenamide trial, that will lead to approval and availability in 2017 or 18. This is still a clear step forward, since at least the bothersome kidney toxicity will then be a thing of the past. It is unclear at this time if the muscle and heart mitochondrial inhibition will also be less with the new compound.
Gilead is currently investing only in dead end approaches in hbv. If anybody will own all the components together is doubtful.This will sadly further delay the performance of proper combo trials.
Tdf + int is in circulation.
Its a credible option potentially sequential combo rates arent good (conversation we had before)
ARC is not in circulation.
As you said you will say whatever you want (clearly without much real intelligent thought behind)
Sounds like you need to grow up. Do some home work instead of using your energy just to br disruptive just some friendly advice
Its a credible option potentially sequential combo rates arent good (conversation we had before)
ARC is not in circulation.
As you said you will say whatever you want (clearly without much real intelligent thought behind)
Sounds like you need to grow up. Do some home work instead of using your energy just to br disruptive just some friendly advice
The drugs currently in trials do not hold the potential for a functional cure in solo mode.
But combinations have a real chance, in particular naps in combo with thymosin or even Pegasys, however to drive the % of real long term responders into a promising range for most, a further combination with the Cuban dual particle vaccine and finally even birinapant will be necessary. A small trial with all these components h a s taken place in a university place far away from the public attention, not for publication but as a proof of principle that such a seroconversion can be truly achieved, even in a case of mutated and integrated e neg hbv phenotypes. It might possibly be poster presented in next year's molecular biology of hepatitis b meeting.
The approval of the treatment components is several years away however or might never come due to some obstacles in the cumbersome way of financing and the difficulties in performing these trials.
But combinations have a real chance, in particular naps in combo with thymosin or even Pegasys, however to drive the % of real long term responders into a promising range for most, a further combination with the Cuban dual particle vaccine and finally even birinapant will be necessary. A small trial with all these components h a s taken place in a university place far away from the public attention, not for publication but as a proof of principle that such a seroconversion can be truly achieved, even in a case of mutated and integrated e neg hbv phenotypes. It might possibly be poster presented in next year's molecular biology of hepatitis b meeting.
The approval of the treatment components is several years away however or might never come due to some obstacles in the cumbersome way of financing and the difficulties in performing these trials.
Do you feel any of the trial drugs currently being tested have a good chance of being approved and being a real shot of a functional cure, especially for us hard to treat HbeAg negative? Sometimes it feels like there are many out there getting close to a real solution and then other times it seems far within reach.
We value your input, and while we do not want false hope from these studies that come through it might be nice to know if (in your opinion) we have any future hope for us living day in and day out with this monster inside of us...or should we just settle in for a long or possibly never road of a functional cure??
We value your input, and while we do not want false hope from these studies that come through it might be nice to know if (in your opinion) we have any future hope for us living day in and day out with this monster inside of us...or should we just settle in for a long or possibly never road of a functional cure??
1 Comments
be sure for atleast one drug addition in hep b line next year, cant say but rumours are strong
i dont know why a pm is not possible. I need to check why this condition exists.
it's the same with offering int+tnf many people are not eligble to that kind of treatment or don't have access to it or can't follow the results of such therapy yet people still pushing this at every oppurtunity like it's some miracalous cure... when the truth it has low seroconversion rate and high risk at stake... and I don't hear people say anything against it... So I will say whatever I want, and I might be right about the arc thing...
Studyforhope.
I notice I cant send you a private message as I would appreciate your opinion on something but I dont want to leave sensitive info on a public thread.
Is there any way I can contact you?
Thankyou for your answers I appreciate them.
Itac
No one accusing you of selling anything or anything like that. but in referance to the initial post its hardly offering a solution suggesting a trial drug thats not in circulation.
I have sent you a private message aswell.
Just a suggestion maybe try and build some bridges with the community rather than consistantly burn them and break them down. Its obvious you probably dont mean harm
I notice I cant send you a private message as I would appreciate your opinion on something but I dont want to leave sensitive info on a public thread.
Is there any way I can contact you?
Thankyou for your answers I appreciate them.
Itac
No one accusing you of selling anything or anything like that. but in referance to the initial post its hardly offering a solution suggesting a trial drug thats not in circulation.
I have sent you a private message aswell.
Just a suggestion maybe try and build some bridges with the community rather than consistantly burn them and break them down. Its obvious you probably dont mean harm
4 years are not a long tme, the mutations might not have developed for some immunedefense critical sequences. But it is all speculation. Only a clonal sequencing can reveal the details of these mutatons and i dont think this is routinely available.
never say never... these drugs might improve... maybe arc-522 will be make it undedectable who knows? with better delivery system that it will reach the hepacytes it might silent all hbsag gene expression... I don't think this is a fantasy, this 99% is only based on current trial with chimps... but it might be even better... Plus I'm sure there are ways to trick the system to by pass these tests, I mean people cheat tests that test for drug usage... I'm sure something like this might exist or already does exist in some underground networks..
And I'm posting all posts with itac screen name, it's 100% (not 99% lol)... My false hopes are no different than int+tnf that is pushed every thread here or maximizing vit d... hypocrisy levels here are crazy!
And I'm posting all posts with itac screen name, it's 100% (not 99% lol)... My false hopes are no different than int+tnf that is pushed every thread here or maximizing vit d... hypocrisy levels here are crazy!
1 Comments
world relies on possibility
Lets say if a patient has been infected approx 4years only became e neg through nucs (after being on NUCS for approx 1year) only on month 10 whilst did the ALT drop "within range".
Do you suspect there is a good chance of mutations in this case?
Do you suspect there is a good chance of mutations in this case?
Most of the T cell activations that help clear out infected cells are associated with at least temporary ALT elevations. But there is a percentage of seroconversions without that. It has most likely to do with the efficacy of the CTl cd8 response that is able , without cell killing, to remove cccDNA from infected hepatocytes, by producing high local levels of interferon gamma and TNf alpha.
Most long standing e neg patients will have mutations in the respective cd8 class i epitopes however, that make this mechanism ineffective.
Most long standing e neg patients will have mutations in the respective cd8 class i epitopes however, that make this mechanism ineffective.
I did want to ask you is it possible of surface sero conversion without an elevated ALT??
I was about to say that. Whats the point in mentioning as a credible solution Arc 520 and Arc521 for this guys problem. Its not like you can pop into your local pharmacy and buy it. My suspicion is they will both flop anyway 520 and 521. Correct me if im wrong but I dont think arrow head has ever got a drug to market.
None of the arcs will make him pass this test. It is important to emphasize this here, since some pour soul in these countries might really think of this as a possibility.
Somebody in this board is pointing out harshly to others not to raise false hopes. It looks like he is mimicking your screen name.
Somebody in this board is pointing out harshly to others not to raise false hopes. It looks like he is mimicking your screen name.
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