Aa
i am suffering from hepatitis B
i have gone through the test the result is as under
comment
in range out of range count
HBsAg deducted
Dr. is giving me lamvir teb. Pl advise can it be abolished fully by this tab.
comment
in range out of range count
HBsAg deducted
Dr. is giving me lamvir teb. Pl advise can it be abolished fully by this tab.
in 2003 i have been detected hbsag positive. LFT was normal. I have no joundice symtopms or any other problem till now. Recently I visited to Dr. He advised me to have LFT test, which is found normal with hbsag positive. I have tested in another lab. The lab also confirmed hbsag detected. The Dr. told me you have only a carrier of hepatits-b only and it is not harming you. After my request of treat this desease, he started lamivir(lumividine). One day an another Dr. was sitting with him, when I visited the Dr. My Dr. take advise from him about this matter. He recommend some tests. HBV DNA,HBc(total),HBc IgM.Now the reports are as under
*HEPATITIS B CORE, TOTAL ANTIBODY
Index Value 0.07
Result: *Reactive *
|*Interpretation:*
| | Index Value |
| 1.001 - 3.000 Non Reactive |
| 0.000 - 1.000 Reactive | |________________________________________________________________|
2.*HEPATITIS B CORE, IgM ANTIBODY*
Index Value 0.27, Result: Non Reactive.(HBV DNA report awaited).
I have taken lumividine for 1 month. Pl. advise what i have to do.
*HEPATITIS B CORE, TOTAL ANTIBODY
Index Value 0.07
Result: *Reactive *
|*Interpretation:*
| | Index Value |
| 1.001 - 3.000 Non Reactive |
| 0.000 - 1.000 Reactive | |________________________________________________________________|
2.*HEPATITIS B CORE, IgM ANTIBODY*
Index Value 0.27, Result: Non Reactive.(HBV DNA report awaited).
I have taken lumividine for 1 month. Pl. advise what i have to do.
Regarding the waistline, since treatment ended I have noticed what I can only describe as abdominal swelling that my doctor put off as weight gain. However, I do not remember my abdomen protruding this much pre-treatment when I was at the same weight (177) and around the same fitness level. Of course, it's possible that the weight lost in tx (I dropped down to 140)came back mostly in the abdomen but I'm still thinking bloating/IBS, etc. I should know more when I get back down to 165-170 which is my target weight on the Zone diet, at least for now. If abdomen is still protruding at that point, have to look at the IBS angle more. Ultrasound showed no fluid in abdomen.
-- Jim
-- Jim
MEDICAL PROFESSIONAL
Jim wrote:
With the Zone, TC was around 170-180, Tri's around 50 and HDL actually nudged up to around 38 if I remember. Since treatment my lipid profile has gotten slightly worse than pre-treatment and my doctor finally admits that the interferon may have amplified the metabolic syndrome that I already apparently had. The other sympton I have is that an hour after a high carb bfkast, I get extremely tired and if don't have work to do will fall asleep on occasion. I've asked my doc about diabetes or pre-diabetes but my glucose is 100 and they said not to worry. The Hgb A1C? test was OK as well.
------------------
From past experience, what I like about the Zone diet is that I had more energy, never tired after meals, and my lipid profile was improved. What I didn't like was that I found it harder to concentrate on pure "thinking" and it seemed to affect my writing. They say carbs feed the brain, and I think they are right but unfortunatly I don't seem to metabolize them very well. The other concern I have about the Zone diet is the amount of protein -- 13 oz or the equivalant of 3 chicken breasts a day while only eating 1600-1800 calories. I should also add that the last time I was on the Zone diet -- 10 years ago -- my liver enzymes elevated. Not sure if this was a function of the diet, my increased exercise levels on the diet or a combination.
I'd like you general impressions on this type of diet but specifically:
(1) Does the diet contain too much protein, and if so, could this be harmful?
I always recommed a diet 1/3 1/3 1/3 , very similar to the Zone diet and basically for similar reasons as Sears does ( I read his book also BTW - smart man). For the protein component, you essentially need amino acids for structural metabolism ongoingly and is the most important component by far. There are caveats, with protein, as with everything, since the molecular biology of life is a huge compromise an many levels. So you need to reduce, by probiotic/prebiotic means, the amount of colonic protein metabolism with toxic - very toxic - byproducts by your intestinal flora. It is unclear to what extent e g the toxic absorption of bacterial amino acid metabolic products, aside from ammonia, can influence the synthetic processes regarding TC, HDl and apolipopoteins that occur in your liver. This is all assumed to add to your genetically pretermined basic lipid/metabolic syndrome profile. What about your abdominal obesity - if any? You can see that the refined discussion of factors weighing in towards modification of the "baseline genetic level" is quickly getting very complex. As I said once, I will be glad to discuss the finer details with you directly. Kalio once asked if she can give my email to you and I of course agreed. You give so much of your time here to others, so you certainly deserve some special attention.
(2) Now that I'm SVR, do you think my enzymes might elevate as before, and if so, what signficance would it have?
It is certainly worth a try. You are of course painfully aware that at this stage of the game your chances of damage by cardiovascular disease are substantially higher than from SVR reversal. When it comes to protecting your liver from metabolic insults/ susceptibilities, interestingly the same measures that hold promise to further reduce remaining fibrosis/functional limitations will also protect you from metabolic/diet induced liver stress. Needless to say, those insults can be as bad as the one from viral infection, as the ever increasing number of cirrhotics from NAFLD clearly demonstrates.
(3) What is your take on the caloric restriction nature of the diet.
Provided the quality of the diet as stated above is in place, the caloric restriction is of an extremely health protective nature. You are surely aware that the only proven effective method to truly dramatically delay the aging process and the degenerative diseases that come with it is caloric retriction. There are fortunately already very serious published results on the dramatic cardiovascular protective nature of caloric restriction in man, mainly from people who have voluntarily subscribed to such an extreme nutritional lifestyle.
With the Zone, TC was around 170-180, Tri's around 50 and HDL actually nudged up to around 38 if I remember. Since treatment my lipid profile has gotten slightly worse than pre-treatment and my doctor finally admits that the interferon may have amplified the metabolic syndrome that I already apparently had. The other sympton I have is that an hour after a high carb bfkast, I get extremely tired and if don't have work to do will fall asleep on occasion. I've asked my doc about diabetes or pre-diabetes but my glucose is 100 and they said not to worry. The Hgb A1C? test was OK as well.
------------------
From past experience, what I like about the Zone diet is that I had more energy, never tired after meals, and my lipid profile was improved. What I didn't like was that I found it harder to concentrate on pure "thinking" and it seemed to affect my writing. They say carbs feed the brain, and I think they are right but unfortunatly I don't seem to metabolize them very well. The other concern I have about the Zone diet is the amount of protein -- 13 oz or the equivalant of 3 chicken breasts a day while only eating 1600-1800 calories. I should also add that the last time I was on the Zone diet -- 10 years ago -- my liver enzymes elevated. Not sure if this was a function of the diet, my increased exercise levels on the diet or a combination.
I'd like you general impressions on this type of diet but specifically:
(1) Does the diet contain too much protein, and if so, could this be harmful?
I always recommed a diet 1/3 1/3 1/3 , very similar to the Zone diet and basically for similar reasons as Sears does ( I read his book also BTW - smart man). For the protein component, you essentially need amino acids for structural metabolism ongoingly and is the most important component by far. There are caveats, with protein, as with everything, since the molecular biology of life is a huge compromise an many levels. So you need to reduce, by probiotic/prebiotic means, the amount of colonic protein metabolism with toxic - very toxic - byproducts by your intestinal flora. It is unclear to what extent e g the toxic absorption of bacterial amino acid metabolic products, aside from ammonia, can influence the synthetic processes regarding TC, HDl and apolipopoteins that occur in your liver. This is all assumed to add to your genetically pretermined basic lipid/metabolic syndrome profile. What about your abdominal obesity - if any? You can see that the refined discussion of factors weighing in towards modification of the "baseline genetic level" is quickly getting very complex. As I said once, I will be glad to discuss the finer details with you directly. Kalio once asked if she can give my email to you and I of course agreed. You give so much of your time here to others, so you certainly deserve some special attention.
(2) Now that I'm SVR, do you think my enzymes might elevate as before, and if so, what signficance would it have?
It is certainly worth a try. You are of course painfully aware that at this stage of the game your chances of damage by cardiovascular disease are substantially higher than from SVR reversal. When it comes to protecting your liver from metabolic insults/ susceptibilities, interestingly the same measures that hold promise to further reduce remaining fibrosis/functional limitations will also protect you from metabolic/diet induced liver stress. Needless to say, those insults can be as bad as the one from viral infection, as the ever increasing number of cirrhotics from NAFLD clearly demonstrates.
(3) What is your take on the caloric restriction nature of the diet.
Provided the quality of the diet as stated above is in place, the caloric restriction is of an extremely health protective nature. You are surely aware that the only proven effective method to truly dramatically delay the aging process and the degenerative diseases that come with it is caloric retriction. There are fortunately already very serious published results on the dramatic cardiovascular protective nature of caloric restriction in man, mainly from people who have voluntarily subscribed to such an extreme nutritional lifestyle.
Thanks! Let me digest both your words and a month of Zone eating and I'll get back. I expect my tri's to fall within a week, but my guess is I'll need a month to see signficant movement in TC and LDL. Don't have to much hope for HDL but maybe I can get it above 35. I'll probably test in 2 and 4 weeks time.
A few quickies.
On and off I've been taking 2 grams daily of Nature's bounty Fish Oil that contains Omega 3 and 6. Also eat salmon and/or sardines probably 2-3 times a week. Now that I'm on the Zone, thinking of bumping it up to 4 grams a day.
What dose would you recommend?
Do you have a favorite brand?
Lastly, what's your position on smoked salmon?
Roobios tea. I drink a lot lately, any comments?
Other than that, taking a multi vitamin and a probiotic. I understand that a more detailed conversation is required for specfic dietary advice, but if I'm missing something obvious like xtra vitamin E, let me know.
Glad you think highly of Sears. A microbiologist friend of mine heard him speak recently and thought he was very together.
-- Still trying to avoid statins,
Jim
A few quickies.
On and off I've been taking 2 grams daily of Nature's bounty Fish Oil that contains Omega 3 and 6. Also eat salmon and/or sardines probably 2-3 times a week. Now that I'm on the Zone, thinking of bumping it up to 4 grams a day.
What dose would you recommend?
Do you have a favorite brand?
Lastly, what's your position on smoked salmon?
Roobios tea. I drink a lot lately, any comments?
Other than that, taking a multi vitamin and a probiotic. I understand that a more detailed conversation is required for specfic dietary advice, but if I'm missing something obvious like xtra vitamin E, let me know.
Glad you think highly of Sears. A microbiologist friend of mine heard him speak recently and thought he was very together.
-- Still trying to avoid statins,
Jim
Sorry guys. I guess I was deceived again. Im not very good on these boards...but Im learning. Please forgive me.
Hi Jmjm, I am trying to avoid talking of all thats wrong with me...I am just SICK of it to be honest. Seems it is one thing after another. Just got off the prednisone, my rash/hives had improved by 70% maybe..and physically felt way better. Then I go back over there and he tells me my "pap" is messed up and the lumps in my breasts are there but he would like to wait and check them again to see if there are any changes before going further in tests. So, ok. I keep getting infections, right now Im on Bactrim for 21 days because the sinus infection got so bad my nose was bleeding out of nowhere...just gush! The pain was emense in my face and head, but I am hanging in there and feeling better. Thanks for asking :) You take care and that diet looks really interesting! Im gonna go read your posts again and do some surfing...cool.
Hi Jmjm, I am trying to avoid talking of all thats wrong with me...I am just SICK of it to be honest. Seems it is one thing after another. Just got off the prednisone, my rash/hives had improved by 70% maybe..and physically felt way better. Then I go back over there and he tells me my "pap" is messed up and the lumps in my breasts are there but he would like to wait and check them again to see if there are any changes before going further in tests. So, ok. I keep getting infections, right now Im on Bactrim for 21 days because the sinus infection got so bad my nose was bleeding out of nowhere...just gush! The pain was emense in my face and head, but I am hanging in there and feeling better. Thanks for asking :) You take care and that diet looks really interesting! Im gonna go read your posts again and do some surfing...cool.
Just wanted to get your take on Barry's Sear's Zone diet which I just started as a last ditch effort to get my lipid profile in tact and therefore avoid taking statins.
In case you're not familiar, in short, the Zone Diet is basically 40 per cent calories from carbs, 30 per cent from protein and 30 per cent from fat. Foods are combined this way every time you eat, so for example you would never just eat an apple (carb) but the apple would be eaten along with a protein source (white meat turkey) and some fat (example almonds). In addition the carbs on the diet are very low on the glycemic index so very little if any bread, pasta, etc. The amount of food eaten is based on a protein requirement based on lean body mass which would probably come out to around 13 oz of protein (3 chicken breasts for example) a day for someone who weighs 170lbs. This also translates into 1600-1800 calories a day for most men, so it is definitely a calorie restricted diet. As to the actual foods eaten, besides using the glycemic index as a guide,
originally there were no specific guidelines, therefore in theory you could eat a meal at McDonalds and be on the Zone if you ordered carefully. Conversly, you could also choose very healthy choices such as organic meats, soy, organic vegetables, etc, for your food choices. I would def tend toward the latter.
---------------
Background: family history of cardivascular disease. High cholesterol on a normal diet (230), low HDL (32) pretty resistent to both exercise, diet and alchol; high tri's over 200. The only two times I have gotten my lipid profile in decent shape was either on the Pritikin diet (under 10 per cent of daily calories in fat calories and no more than 3oz lean meat a day) or on the Zone diet. With Pritkin, my TC dropped to 150-160 but tri's stayed above 200 and HDL dropped to 29. With the Zone, TC was around 170-180, Tri's around 50 and HDL actually nudged up to around 38 if I remember. Since treatment my lipid profile has gotten slightly worse than pre-treatment and my doctor finally admits that the interferon may have amplified the metabolic syndrome that I already apparently had. The other sympton I have is that an hour after a high carb bfkast, I get extremely tired and if don't have work to do will fall asleep on occasion. I've asked my doc about diabetes or pre-diabetes but my glucose is 100 and they said not to worry. The Hgb A1C? test was OK as well.
------------------
From past experience, what I like about the Zone diet is that I had more energy, never tired after meals, and my lipid profile was improved. What I didn't like was that I found it harder to concentrate on pure "thinking" and it seemed to affect my writing. They say carbs feed the brain, and I think they are right but unfortunatly I don't seem to metabolize them very well. The other concern I have about the Zone diet is the amount of protein -- 13 oz or the equivalant of 3 chicken breasts a day while only eating 1600-1800 calories. I should also add that the last time I was on the Zone diet -- 10 years ago -- my liver enzymes elevated. Not sure if this was a function of the diet, my increased exercise levels on the diet or a combination.
I'd like you general impressions on this type of diet but specifically:
(1) Does the diet contain too much protein, and if so, could this be harmful?
(2) Now that I'm SVR, do you think my enzymes might elevate as before, and if so, what signficance would it have?
(3) What is your take on the caloric restriction nature of the diet.
Thanks for all your help.
-- Jim
In case you're not familiar, in short, the Zone Diet is basically 40 per cent calories from carbs, 30 per cent from protein and 30 per cent from fat. Foods are combined this way every time you eat, so for example you would never just eat an apple (carb) but the apple would be eaten along with a protein source (white meat turkey) and some fat (example almonds). In addition the carbs on the diet are very low on the glycemic index so very little if any bread, pasta, etc. The amount of food eaten is based on a protein requirement based on lean body mass which would probably come out to around 13 oz of protein (3 chicken breasts for example) a day for someone who weighs 170lbs. This also translates into 1600-1800 calories a day for most men, so it is definitely a calorie restricted diet. As to the actual foods eaten, besides using the glycemic index as a guide,
originally there were no specific guidelines, therefore in theory you could eat a meal at McDonalds and be on the Zone if you ordered carefully. Conversly, you could also choose very healthy choices such as organic meats, soy, organic vegetables, etc, for your food choices. I would def tend toward the latter.
---------------
Background: family history of cardivascular disease. High cholesterol on a normal diet (230), low HDL (32) pretty resistent to both exercise, diet and alchol; high tri's over 200. The only two times I have gotten my lipid profile in decent shape was either on the Pritikin diet (under 10 per cent of daily calories in fat calories and no more than 3oz lean meat a day) or on the Zone diet. With Pritkin, my TC dropped to 150-160 but tri's stayed above 200 and HDL dropped to 29. With the Zone, TC was around 170-180, Tri's around 50 and HDL actually nudged up to around 38 if I remember. Since treatment my lipid profile has gotten slightly worse than pre-treatment and my doctor finally admits that the interferon may have amplified the metabolic syndrome that I already apparently had. The other sympton I have is that an hour after a high carb bfkast, I get extremely tired and if don't have work to do will fall asleep on occasion. I've asked my doc about diabetes or pre-diabetes but my glucose is 100 and they said not to worry. The Hgb A1C? test was OK as well.
------------------
From past experience, what I like about the Zone diet is that I had more energy, never tired after meals, and my lipid profile was improved. What I didn't like was that I found it harder to concentrate on pure "thinking" and it seemed to affect my writing. They say carbs feed the brain, and I think they are right but unfortunatly I don't seem to metabolize them very well. The other concern I have about the Zone diet is the amount of protein -- 13 oz or the equivalant of 3 chicken breasts a day while only eating 1600-1800 calories. I should also add that the last time I was on the Zone diet -- 10 years ago -- my liver enzymes elevated. Not sure if this was a function of the diet, my increased exercise levels on the diet or a combination.
I'd like you general impressions on this type of diet but specifically:
(1) Does the diet contain too much protein, and if so, could this be harmful?
(2) Now that I'm SVR, do you think my enzymes might elevate as before, and if so, what signficance would it have?
(3) What is your take on the caloric restriction nature of the diet.
Thanks for all your help.
-- Jim
Here is a more scienfitic description of the Zone diet from their web site:
" (Dr. Sears)research has led to patents in the area of hormonal control by essentially using food as an oral drug delivery system to modulate eicosanoids, especially for cardiovascular and diabetic patents. "
http://www.zoneliving.com/ZoneScience/tabid/57/Default.aspx
" (Dr. Sears)research has led to patents in the area of hormonal control by essentially using food as an oral drug delivery system to modulate eicosanoids, especially for cardiovascular and diabetic patents. "
http://www.zoneliving.com/ZoneScience/tabid/57/Default.aspx
I should add that the numbers I gave on a "normal" diet are actually numbers on what most would consider a very healthy diet. For whatever reason, my cholesterol and tri's only seem to move downward in a meaningful fashion if I make a very significant change in diet -- either something like the Zone or the very fat restricted Pritikin diet.
MEDICAL PROFESSIONAL
Kataria, you asked the same question already twice before and it was answered. You did not respond to the answer.
It is not wise to restart a thread and ignore previous answers, it will then simply be ignored, because it seems you are ignoring the answers and efforts made.
Here is one answer I gave you 4 days ago:
"Lamivudine cannot cure Hepatitis B. The virus develops resistance rather fast with irreversible consequences. It can be given with simultaneous Hepsera(Adefovir Dipivoxil.
It should not be used as monotherapy anymore!!! It often is still used in this way because it is the least expensive drug and many Drs do not know the full impact of this resistance on the future of the patients treatment chances.They try, wait for failure and then "switch" to the next drug. Bad, bad strategy because the other drugs work then less effectively and are more prone to further resistance once the YMDD backbone mutation is in place.
Which country are you from? To give any more specific comments much more info would be needed. HBV is a complex multitude of diseases "
It is not wise to restart a thread and ignore previous answers, it will then simply be ignored, because it seems you are ignoring the answers and efforts made.
Here is one answer I gave you 4 days ago:
"Lamivudine cannot cure Hepatitis B. The virus develops resistance rather fast with irreversible consequences. It can be given with simultaneous Hepsera(Adefovir Dipivoxil.
It should not be used as monotherapy anymore!!! It often is still used in this way because it is the least expensive drug and many Drs do not know the full impact of this resistance on the future of the patients treatment chances.They try, wait for failure and then "switch" to the next drug. Bad, bad strategy because the other drugs work then less effectively and are more prone to further resistance once the YMDD backbone mutation is in place.
Which country are you from? To give any more specific comments much more info would be needed. HBV is a complex multitude of diseases "
Hi Mkella,
I do remember Katrina posting this a few days ago and HR's answer. I wish I could add something but know next to nothing about Hep B. How are you doing these days?
All the best,
-- Jim
I do remember Katrina posting this a few days ago and HR's answer. I wish I could add something but know next to nothing about Hep B. How are you doing these days?
All the best,
-- Jim
MEDICAL PROFESSIONAL
I have answered Katarias posts twice, there was no further response to that ,just a reposting of the same question.
In a short answer Lamuvidine does not abolish the virus. It controls it and may make it stop replicating so much.
There are newer drugs on the market that are much better than Lam but without knowing which country you live in I cannot help.
However these newer drugs are more expensive than Lam.
There are newer drugs on the market that are much better than Lam but without knowing which country you live in I cannot help.
However these newer drugs are more expensive than Lam.
My apologies in advance for not remembering who has Hep B
It just seems to me that these two names ring a bell in that area (maybe due to knowledge)...please forgive me if I am wrong, and clarify if you would. So sorry...I just feel bad for kataria...I have seen MANY posts with that moniker and no responses.
It just seems to me that these two names ring a bell in that area (maybe due to knowledge)...please forgive me if I am wrong, and clarify if you would. So sorry...I just feel bad for kataria...I have seen MANY posts with that moniker and no responses.
Hi kataria. Sorry there hasn't been many comments to your posts but I think maybe it is because you need to expand on your question and what is going on with you. I think the majority here have or are suffering from Hep C, but I KNOW there are many with Hep B. I will do a "call out" to a few I believe are Hep B. I couldn't find anything about the med you wrote, but this is the closest (in spelling?) I could find anything about. If it is the same, it looks like your Dr. may know what he is doing. The last paragraph sums it up :) I am so sorry you have to go through what you are. Good luck. I recieved this from:
http://www.aafp.org/afp/20000315/tips/4.html
Lamivudine Is Effective for Chronic Hepatitis B
It is estimated that approximately 300 million people worldwide are infected with hepatitis B virus. In Asia, most persons are infected perinatally and are usually asymptomatic, but remain chronically infected. In the United States and other Western countries, most people acquire hepatitis B through sexual transmission or intravenous drug use. These persons usually become acutely ill; however, only about 10 percent become chronically infected. In this subset of patients, the only effective treatment to date has been interferon. Some recent studies have suggested that lamivudine, an oral nucleoside analog used to treat patients infected with the human immunodeficiency virus (HIV), is also effective in the treatment of hepatitis B. Dienstag and colleagues performed a randomized, placebo-controlled trial of lamivudine in patients with chronic hepatitis B infection.
Patients with a history of chronic hepatitis B infection were eligible for the study. Entry criteria included an age of at least 18 years, serology positive for hepatitis B surface antigen (HBsAg) for at least six months, hepatitis B e antigen (HBeAg) for at least one month and an elevation of the alanine aminotransferase (ALT) level that was 1.3 to 10 times the upper limit of normal for at least three months. Additional criteria were evidence of chronic hepatitis B infection on liver biopsy and a detectable level of serum HBV DNA. Excluded were patients previously treated with interferon or lamivudine, a history of significant hepatic dysfunction including a bilirubin level higher than 2.5 mg per dL (43
http://www.aafp.org/afp/20000315/tips/4.html
Lamivudine Is Effective for Chronic Hepatitis B
It is estimated that approximately 300 million people worldwide are infected with hepatitis B virus. In Asia, most persons are infected perinatally and are usually asymptomatic, but remain chronically infected. In the United States and other Western countries, most people acquire hepatitis B through sexual transmission or intravenous drug use. These persons usually become acutely ill; however, only about 10 percent become chronically infected. In this subset of patients, the only effective treatment to date has been interferon. Some recent studies have suggested that lamivudine, an oral nucleoside analog used to treat patients infected with the human immunodeficiency virus (HIV), is also effective in the treatment of hepatitis B. Dienstag and colleagues performed a randomized, placebo-controlled trial of lamivudine in patients with chronic hepatitis B infection.
Patients with a history of chronic hepatitis B infection were eligible for the study. Entry criteria included an age of at least 18 years, serology positive for hepatitis B surface antigen (HBsAg) for at least six months, hepatitis B e antigen (HBeAg) for at least one month and an elevation of the alanine aminotransferase (ALT) level that was 1.3 to 10 times the upper limit of normal for at least three months. Additional criteria were evidence of chronic hepatitis B infection on liver biopsy and a detectable level of serum HBV DNA. Excluded were patients previously treated with interferon or lamivudine, a history of significant hepatic dysfunction including a bilirubin level higher than 2.5 mg per dL (43
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