What will be the result on blood test a patient can stop Entecavir treatment
no result drugs can t eradicate hbv they just stop the damage, only if hbsag becomes negative and hbsab>10miu/ml you can stop after 6 months but this happens on 3% hbe neg and 5% hbe pos
the drug is to avoid cirrhosis and liver cancer due to virus replication so it is a life treatment, maybe hbsag will get very low in 10-15 years but nobody has used it more than 6years because drug is new
Is HBsAg same as HBV DNA?
two things complitely different with no correlation, hbsag are the surface particles of the virus for attachment to liver cells but also particles without the virus produced in excess by cccdna to neutralize hbsab antibody, this antibody blocks the entrance to liver cells for the virus.
hbvdna is not the number of virions in the blood and in the liver but reflects the number of replicating virus in a certain time, its sensitivity is very low in terms of virological response, immune control of virus etc but that's what we got for now, the real tests needed to see what happens in the liver are cccdna quantity and hbvdna quantity in the liver, tests available now in very specialized labs with biopsy but soon available by blood
quantification of hbsag can reflect immune response potency and cccdna quantity and also predict if hbsag clearance is possible, this test is in iu/ml only and not available in US/canada while available in europe, asia, china
What does it mean;
3% hbe neg and 5% hbe pos ?
the percentage of patients making hbsag neg and hbsab pos on hbeag neg and hbeag pos.etv is the only with hbsag seroconversion on hbe neg, tdf has 0% and interferon also very low
after stopping entecavir treatment for 6 months
3% of the patents has seroconvert
hbsag - negative
absolutely not, antivirals cannot be stopped, only if hbsag becomes negative and hbsab>10 you can stop but not immediately you have to keep taking drug at least 6 months even after hbsag is neg
I might be in that 3%. If my understanding is wrong please correct me. TIA
yes but you musy keep taking drug anyway and not seroconverted yet because your hbsag is still positive
If hbsab > 10 miu/ml whether indicated replication becoming active again? Will the patient infect other persons?
this is antibody to block hbv entrance in to cells, this should make hbsag negative by 6-12 months while taking etv
Does "HBV DNA" level indicate replication active? If YES, please advise its value which the patient may infect other persons, additionally exposing to danger of cirrhosis.
hbvdna is only to see if drug is working, it is not a sensitive test and when hbvdna is und means only low replication
you will be always infectious by blood even if you clear hbv, when hbvdna is und you are not infectious by saliva and much less by seamen
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