After 16 week with Interferron + Simvastatin

[Otan]

Took 1st dose on 21 Oct 2011 and on 11 Jan 2012 HBV DNA not detected.  
Below is the lab history,                          

Date            13/9  20/10  21/10  11/11  16/11  9/12  15/12  6/1/12  11//1/12
                                   1st dose                                   12th dose
SGOT                    35*                          49*             63*                  67*
SGPT                    63*                          78*             89*                  90*
HBsAg     366.44  255.68                                                              176.4*
HBV DNA2.54x10^5                                                                   no detect

Result on week# 16

SGOT  86
SGPT  130
HBsAg  10.49

When HBsAg became zero, then what to do? Is that time to stimulate Anti-HBs?

[grmr]

so what mild sides?

[stef2011]

http://www.medhelp.org/posts/Hepatitis-B/HBV-almost-cleared-12-weeks-with-interferonsimvastatin/show/1676186

[Otan]

Sorry to reply late, I was at remote location internet access limited.

May I ask what status you were in before treatment? Were you on antivirals before, your hbseg status, etc? Thanks.
Before interferron treatment I did nothing at all since I felt healthy. I do the treatment becoz I lost my overseas job.

Before treatment
SGOT                    35*    
SGPT                    63*  
HBsAg                255.68  
HBV DNA         2.54x10^5    
HBeAg             non reactive
Anti HBe           reactive

Byopsi result
Chronic Heps B Metavir grade-1, stage 1.

[Otan]

i join lema2210 question.. pls inform about your status prior to tx.
pls see, i ve answer lema2210

were you hbv carrier since birth?
more probably, I have my brother has HBV. Mother never check but healthy now 78 years.

I am 47 now.


are you experiencing side effects on iterferon?

Below is my experience with Interferron teraphy,
At 1st injection, Doctor asked me to stay at hospital for 24 hrs to see the effect, but everything felt normal. Same thing happen with 2nd injection.
After 3rd injection, started feel flu symptons , dry mouth (thirsty), less taste for food (my portion still normal) but still feel strong
After 4th injection, feel headache, sleepy/weak, less taste for food  and itching. But I still can riding bicycle for exercise.
After 10th injection, sometime light headache, dry mouth,  itching , less taste for food  but feel little stronger.
But now itching is less.

[Otan]

it can also be important if there was use of anticholesterol drugs/statins before interferon and how long

No , interferron come together with simvastatin

[stef2011]

you ll sure get your job back now, hbsag is already negative at 0....iu/ml, we just have to wait for hbsab to rise