Combo Treatment: Baraclude + Viread (results)

[hepbinme]

Hey guys, I'm new to the forum -- I just found the thread through Google by searching Viread + Baraclude. My apologies if I ask a few stupid questions, I'm still learning a lot about HepB. =]

I want to start off by saying that I have been taking both Baraclude + Viread as part of a study in November. I will try to be specific as possible, but all my paperwork and results are back at home since I'm away for college. I'm a 23 year old Asian male and found out I had chronic HepB.

---------------------------------------------------DATA---------------------------------------------------
• 1st blood results were (taken in 07/18/2008). NOT ON TREATMENT
HEPATITIS B VIRAL DNA, QUANT PCR             1,630,000,000 H    <160 copies/mL

• 2nd blood results were (taken in 08/19/2008). NOT ON TREATMENT
HEP B VIRAL DNA QT                                      1,020,000,000 H     <160 copies/mL
                                                *some fluctuation in numbers, but still very high

         ♦I started the combo drugs sometime in November with the high DNA count above, if not more.

• 3rd blood results were (taken in December 2008): ON TREATMENT
HEP B VIRAL DNA QT                                      300,000 H     <160 copies/mL

• 4th blood results were (taken in January 2009): ON TREATMENT
HEP B VIRAL DNA QT                                      801 H    <160 copies/mL

• 5th blood results were (taken in April 2009): ON TREATMENT
HEP B VIRAL DNA QT                                      201 H     <160 copies/mL

My doctor said the goal is to get my HepBeAG to turn negative as it is the engine behind the whole process, and the viral count to Zero.

At the moment, I'm HepBeAB negative, and HepBeAG positive.

Please feel free to ask any questions, and hopefully I'll be able to do the same as well as provide answers.

Thanks everyone! Will keep everyone up to date!

[stef2011]

viread cannot be used on those with kidneys disfunction, i am one of those....but fibroguard is able to repair kidneys and lower creatinine, i do think you should try fibroguard and see if you can tollerate viread, this is because once you hve epivir (lamivudine) resistance there are no drugs except tenofovir

what combo are you going to make?without tenofovir there are no comboes that can work on you

you may try: interferon+tenofovir (viread) but i d never use entecavir even in combo because with epivir resistance you are already resistant to etv

[phihungmd]

Are you treated in this study :"Entecavir Plus Tenofovir Combination Therapy Versus Entecavir Monotherapy in Naive Subjects With Chronic Hepatitis B" ?
How about your test ?

[nayana_]

I am about to start combo treatment.
What was your drug combination dosage?
I developed resistance with epivir so I can not use baraclude alone and Viread is too toxic so we are going to try combo treatment so I am interested in your Recipe.

[stef2011]

good to know this combo can be stopped on hbe seroocnversion by using only one drug.do you know the reason to use entecavir instead of tenofovir since it is a weaker drug?you have also to consider that tenofovir has 16% hbsag seroconversion by 3 years on hbeag positive at start of therapy so entecavir was really a bad choice since hbsag seroconversion is much lower than tenofovir for you

did they measure your hbsag quantity?

are you still with the researchers now or switched to normal liver specialists?i guess the next best move is a combo of entecavir with immune modulators like interferon and alinia

[hepbinme]

Update! Sorry for the delay.

@bram44: 0 H count is definitely a first step. However, I have not sero converted. Until around November, 2010, my combo treatment ended and I was transferred onto another study, but only on one medication: Baraclude.

@longman555: I live in California.

@stefano170669: What is "immune tollernat fase"?
• I was only notified of my Chronic HepB. I only had a liver ultrascan which did not show signs of tissue scarring.
• No adverse kidney issues.
I feel normal. Been trying to train for a half-marathon happening next weekend.

I am now on Baraclude, one pill a day.

[stef2011]

sorry i confused this is not a good example: he had hbs-ab by vaccine but when got hcv hbs-ab disappeared and got hbv as well, it was very bad luck because got viruses from a needle

but what i meant is that some virus is left in the body even after hbs-ab so taking viread is not bad because you can reach a similar state taking a viread pill