Entecavir + Interferon combo

[cyrus131]

Dear all,

     I have been on Entecavir 0.5mg for over 6 years and my HBV DNA is nearly undetectable.  I will see my doctor tomorrow and what tests should I perform so as to assess whether I will benefit from the Entecavir + Interferon combo treatment (i.e. higher chance to achieve Hbsag seroconversion.)  Many thanks.

Regards,

Cyrus

[cyrus131]

Dear Stefano and studyforhope,

Sad news indeed.  I rechecked my HBsAg on 10 September 2014 and got my result today that my HBsAg is 'POSITIVE' again i.e. my Hep B relapsed!

I have discontinued my interferon as scheduled (after 48 weeks) after I developed Anti-HBs in March 2014.  I have not ceased and still continued to take entecavir 0.5mg daily as a precaution advised by you.

I did not get the vaccines (which I am terribly regretted).  Kindly let me have your expert opinions.  Many thanks.

Regards,

Cyrus

[rain_ai]

I HOPE THE DOCTOR CAN FIND CURE OF IT. I AM HOPEFUL TOO

[calebz]

good to see you folks are getting good responses :)

[Alwspositive]

How exactly can one find a good, non biased,  knowledgeable doctor?? Thanks

[andrey19]

I think there is always chance for hbsag relapse even when you test neg after inf course and in order to decide weather you need to go for next peg shot or maybe even go prolonged course you need to monitor your hbsag kinetics while on treatment. Just imagine if you were still hbsag positive on week 44 and started bebing neg on week 48. Is it wise to stop inf right away? or maybe prolong inf for a couple of month or so?

[stef2011]

that s guidelines once hbsag neg and hbsab pos the antiviral must be kept to normalize and consolidate immune response (remember cccdna is still there)

i believe only italian guidelines took care of this, very few countries around the world are actually curing hbv patients and taking care of consolidation...maybe only few words about this by researchers/most expert liver specialists