Fibrosis progression rates between chronic hepatitis B and C patients with
elevated alanine aminotransferase levels.
Fujiwara A, Sakaguchi K, Fujioka S, Iwasaki Y, Senoh T, Nishimura M, Terao M,
Department of Gastroenterology and Hepatology, Okayama University Graduate
School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata,
Okayama, 700-8558, Japan.
BACKGROUND: We evaluated the annual rate of fibrosis progression in chronic
hepatitis B and C patients with elevated alanine aminotransferase (ALT)
levels. METHODS: Forty-nine chronic hepatitis B patients and 21 chronic
hepatitis C patients, each of whom had undergone two or more liver biopsies at
an interval of more than 1 year, were enrolled in this retrospective clinical
research protocol. The annual rate of fibrosis progression was calculated by
dividing the change in fibrosis stage between the first and second liver
biopsies by the interval in years between them. RESULTS: The median interval
in chronic hepatitis B and C was 3.4 (first and third quartiles, 1.8-4.7) and
3.2 (2.1-6.5) years, respectively. Overall, the mean fibrosis progression rate
was 0.21 +/- 0.31 (mean +/- SD) fibrosis units (FU) per year in 49 patients
with chronic hepatitis B, and 0.13 +/- 0.18 FU/year in 21 patients with
chronic hepatitis C. The ALT level was an independent variable correlating
with fibrosis progression. In patients whose median ALT level was 70 IU/l or
more, the mean fibrosis progression rate was 0.28 +/- 0.32 FU/year in 36
patients with chronic hepatitis B, and 0.22 +/- 0.23 FU/year in eight patients
with chronic hepatitis C. CONCLUSION: This paired-biopsy study of untreated
chronic hepatitis B or C demonstrated that fibrosis progression occurred
largely in patients with continuously elevated ALT levels even over a
relatively short period, and that liver fibrosis might progress by one stage
within an average of 4-5 years of follow-up in patients with elevated ALT of
70 IU/l or more.
I saw this one this morning. It was interesting for me because I have had elevated ALT for at least 10 years. Mine never got over 69 and is more typically in the 40s. I liked this study b/c it gave particulars about ALT instead of the more general 1.5 x ULN where normal is not stated.
Copyright 1994-2016 MedHelp International. All rights reserved.
MedHelp is a division of Aptus Health.
This site complies with the HONcode standard for trustworthy health information.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Med Help International, Inc. is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.