HBV almost cleared 12 weeks with interferon+simvastatin

[Otan]

Below is my experience with Interferron teraphy,
At 1st injection, Doctor asked me to stay at hospital for 24 hrs to see the effect, but everything felt normal. Same thing happen with 2nd injection.
After 3rd injection, started feel flu symptons , dry mouth (thirsty), less taste for food (my portion still normal) but still feel strong
After 4th injection, feel headache, sleepy/weak, less taste for food  and itching. But I still can riding bicycle for exercise.
After 10th injection, sometime light headache, dry mouth,  itching , less taste for food  but feel little stronger.

Below is the Lab test history, after dose#12 HBV DNA not detected.

                        Base line 1st dose 4th dose         8th dose         12th dose                Ref. Range   Unit
Date:      13-Sep-11 20-Oct-11 21-Oct-11 11-Nov-11 16-Nov-11 09-Dec-11 15-Dec-11 06-Jan-12 11-Jan-12
AST (SGOT)                    35*                             49*            63*                     67* <33            IU/L
ALT (SGPT)                    63*                             78*             89*             90* <50           IU/L

HBsAg        366.44* 255.68*                                                   176.4* <0.05 IU/mL

HBV-DNA     2.54 x 10^5 2.54 x 10^5                                 no detectd         

Thanks.  

[Otan]

Stef, below is the recent mail from Dr Chan, and I am thinking of visit him to Hong Kong.

Dr Chan;

I need few question for you.
-What is your Clinic/ Hospital address/telp in Hong Kong?
-Before I will do this all, do I need to check my HBV DNA and HBsAg again because last check were
  11 Jan 2012:  HBV DNA - undetected
  13 Feb 2012: HBsAg- 0.02 (negative)
   I never miss interferron injection and still doing this till now.
- How much money I should prepare for this vaccination.


Dear OTAN:
I think you need the use of Thymosine 3.2 mg to booster up your immune system and give your self a triple dose of the new subunit vaccine at the same time.  You need altogether three doses given on Day 1, day 30 and day 180. If you come to Hong Kong, we can give you the first dose and let you bring back the rest of the vaccines and Thymosine with you to Indonesia where you can administer them yourself. David Chan.

[stef2011]

forgot about hiv, that same patient is also hivrna undetactable or extremely low hivrna without hiv drugs and his cd4 are very high in the normal range, he is still on gcmaf and off any drugs

[stef2011]

very good to have help from these expert doctors/researchers, you may also use gcmaf to henance immune system like i am doing and that will help for sure but i guess it is difficult to get it in your area in a very short tie and it is pretty expensive, one vial 660euro for 2 months treatment shipment included.the point is it loses potency if delivery is longer than 3-4 days because it needs temp at around 4° to store it with no losses

an hiv+hbv coinfected patient in italy used gcmaf injections and cleared hbv by 4 weeks on gcmaf.he was not infected at birth because hbcab igm positive but since coinfected with hiv he was not clearing hbsag and was over 6 months of infection, gcmaf cleared immedialy hbsag and developped hbsab.you may find gcmaf at this website, gcmaf eu

[Otan]

This is my mail conversation with Dr Chan david you sent me. I have to find Doctor who will give vaccination;
Start from very bottom.



Dear Otan:
I am sorry that I have no contact in Singd you tooapore or Indonesia that I can send you too, but if you come to Hong Kong, I can start the treatment that I have used to treat my other patients and induced antibodies in them. Continuation of interferon would not help with your antibody production but it would probably protect you from flaring up of your hepatitis B .
I will be attending a conference in Ching Mai in Thailand in June . Would you be coming to this meeting on hepatitis? I can discuss your situation with you if you attend this conference. David Chan.

From: OTAN
Dr Chan;

I have seen doctor at Jakarta in my place and consult about vaccination but they said just continue with interferron.
Do you have doctor friend in Singapore or Penang that will do that?

From Dr Chan:
DEAR OTAN:
cONGRATULATIONS YOU HAVE SHOWN GOOD RESPONSE TO INTERFERON AND YOUR hbs ANTIGEN IS DOWN TO o.O2 WHICH IS BASICALLY NEGATIVE. hOWEVER, UNTIL YOUR BODY CAN DEVELOP ANI hbs ANTIBODY YOU ARE NOT CURED YET AND THREE OF MY PATIENTS RECURRED AFTER BECOMING hbs ANTIGEN NEGATIVE AND THEN STOPPING ALL TREATMENT.


i WOULD RECOMMIND THE FOLLOWING; yOU MUST ENHANCE YOUR BODY'S IMMUNE MECHANISM TO HELP YOU PRODUCE ANTIBODIES. i WOULD RECOMMEND STARTING YOURSELF ON ALPHA ONE THYMOSINE 3.2 MG TWICE WEEKLY FOR 4 WEEKS AND THE GIVE YOUR SELF A TRIPLE DOSE OF HEPATITIS b SUBUNIT VACCINE , REPEAT THE ABOVE IN 4 WEEKS TIME AND THEN A SECOND DOSE OF TRIPLE HEPATITIS b VACCINE. THEN CHECK AND SEE IF ANY ANTIDOY DEVELOPS AND LET ME KNOW WHAT YOUR RESULTS ARE. i LIKE TO FOLLOW YOUR CASE UP WITH YOU AND BEST OF LUCK.   DAVID CHAN.


From:OTAN
Dr Chan
I am on interferron week# 18.
I am now HBsAg - 0.02 iu/ml (last check) ; HBV DNA- undetected and HBsAb- negative

What should I do to stimulate anti HBs?
Lab result attached.

[stef2011]

is the simvastatin dose 10mg?might that be realated to simvastatin?

if there is any chance it can be due to sim i d lower sim to 5mg and see how alt changes

i actually think 99% is still the hbv fight, it will end when hbsab will rise because hbsab will prevent reinfection of other cells and all the infection gets halted definitely

[Otan]

7/3/12 ALT 161