HBeAg negative Undetected viral load

[Ram1982]

Hi All,

As there is no medication is required for HBeAg negative with undetectable viral load, being in this state is harmful? Because we never know without any treatment wat is going to happen to our liver?

New medicines which are being invented are targeting such patients also? Or this is the state everyone would like ti be in as immune system is controlling virus?

[Ram1982]

Thanks sorte for your suggetion.

[sorte]

your hbsag is much lower then average, most hbe- people have it around 10000-20000, even if you won't start therapy you should monitor it at least once a year to check if it goes down by itself cuz you have und viral load so it's good.

[Ram1982]

Hi Stef/Sorte,

Thanks for your information. I am from India and travelling to US next month. Is there any tablet can I take to lower HBsAg count instead of injection which keeps me away from risks of HCC and Liver failure?

I am HBeAg negative with undetected viral load with normal liver function tests and HBsAg count 4400 ui/ml.

May be once I get HBsAg count lesser than 1000 ui/ml after few years, I can add peg to it as per your suggestion.

[sorte]

exactly, most doctors don't care about HBsAg quantitive and they qualify everyone with und hbv dna and normal ALT as inactive carrier, what is not always true

[stef2011]

it is also important to note that hbeag neg with hbvdna undetected but hbsag higher than 1000iu/ml is still at increased HCC risk vs hbeag pos with high hbsag.....so future therapies are trying to target hbsag to lower it, we also have peginterferon to lower hbsag and it worths trying 12 weeks to see if hbsag goes down and there are no sides, in case of sides or no hbsag decline peg can be stoped

[hepbcurepls]

As there is no medication is required for HBeAg negative with undetectable viral load, being in this state is harmful? Because we never know without any treatment wat is going to happen to our liver?

The phase you are referring to is considered inactive phase where hbv dna is undetectable, alt normal and hebag negative. some stay in this state for decades of forever while others immune escape.

New medicines which are being invented are targeting such patients also? Or this is the state everyone would like ti be in as immune system is controlling virus?

the new medicines are targeting every aspect of hepatitis b from viral control to boosting immune response. inactive phase still has its risk with hcc but at a lower risk compared to chronic hbv. you can go to

http://www.hepb.org/professionals/hbf_drug_watch.htm

this website will give you a better understanding of what drug is currently being developed and what it will be used for. I have heard 95% of drugs in clinical trials never make it. But there is always hope as cuban vaccine nasvac seems promising for add on to nucs.