Peginterferon Therapy for HBeAg-Negative Chronic Hepatitis B

[ytdthjznyj]

http://www.nature.com/ajg/journal/v105/n8/full/ajg2010187a.html

[stef2011]

the article is right but since you can try interferon and see if you fall in the low percentage of seroconverters by 12 weeks it is good to try

the latest research shows that the best therapy is combo:
start with entecavir or tenofovir better if combo with nitazoxanide and then when hbvdna und and normal alt make staggered or combo peginterferon

the theory is when hbvdna gets und by entecavir or tenofovir the immune system suppression by hbv is much less and peginterferon can work better, on small studies and report cases this staggered combo therapy has lead to very good results and higher hbsag seroconversions

nitazoxanide pretreatment will make interferon much more effective, i think that showing monotherpy studies is very stupid now since they lead nowhere as regards immune control of hbv or hbv cure

[ytdthjznyj]

Stefano, thanks a lot for your comment, but can you please explain what exactly means the "staggered combo therapy"?

[stef2011]

i posted some links to studies before because they are very interesting, it means when hbvdna und you stop NUC (keep only ntz if using it) and start peginterferon for about 6-12 months then when finished restart nucs+ntz, all this until hbsag seroconversion

we don t know what's better if staggered or combo nuc+interferon, trialas are ongoing.we know from old trials (except the ridiculous lamivudine which is way too weak) that peginterferon+adefovir lowers hbsag and cccdna more than respective mono, so entecavir and tenofovir should be even stronger