Hi, I have a member in family with chronic hepatitis B, probably infected 16 years ago, when she had the symptoms of acute hepatitis B, including jaundice (she is also positive for HAV antibodies). She didn't know that she was infected with HBV until 2003 I think, when she went to donate blood.
Until this year when I read about HBV, she did only ALT & AST tests. She didn't take any medication.
HBsAg reactive (3.0 OD, 0.077 cut-off),
HBeAb reactive (0.004 OD),
HBcAb reactive (0.008)
HBV DNA 47000 copies/ml.
This month I was curious to test her for HBsAb (Anti-HBs).
The test was reactive 15 mIU/ml:
reactive > 12 mIU/ml
border line > 8 mIU/ml & < 12 mIU/ml.
negative < 8 mIU/ml.
What could this mean?
Is her HBsAg suffered some mutation?
If it's a mutation, than why the HBsAg it's detected?
HBsAb is actually found in a decent percentage of chronic B Heppers. But it pretty much useless since it probably directed against a different HBV genotype or the virus has mutated B-cell epitopes so this antibody cannot form an immune complex to neutralize its true HBsAg.
What's terrible about this situation is that many many doctors don't know about this and they assume that the person is immune or in the "grey area" so on its way to clearing the virus. This is true for an acute HepB infection. But if your HBsAg is positive for over, say a year, you have chronic HepB regardless of your HBsAb result. Yes, having false hope suck...been there. Hey at least, some of us could answer these question now to establish info on the net. When I was looking for this specific answer, there was nothing. One of the few times that goggle searches failed. There was nothing.
Copyright 1994-2016 MedHelp International. All rights reserved.
MedHelp is a division of Aptus Health.
This site complies with the HONcode standard for trustworthy health information.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Med Help International, Inc. is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.