I have fibrosis

[aberdeen577]

Dear All,
I have just joined the forum today and I have read many threads already over the last few months. I want to now start taking more care AND control.
My history is that I have had hep b since 1991. I had biopsy then and my liver was fine. The consultant put me on alpha interferon for 6 months but it did no good or so I was told. Over the next few years I was put on lamivudine and then combo with adefovir. In 2007 I was taken off combo and my hbvdna fluctuated between und and 2000/3000. Recently I had a fibroscan which was inconclusive (But showed around 11.7 kpa). I then had a second biopsy whic showed that I have fibrosis between stage 3 and 4. I was immediately put on tdf and have been on it now for a year.Having said all that I feel great and do lots of exercise in the gym 3/ 4 times a week. I can run 10k on treadmill in 55 minutes.
I take a 1500mg krill oil tablet each day; 3x 60mg blueberry extract ;1000mg garlic and 1 selenium ACE.

I have seen what tests needs to be done in other threads here and I intend to get them done soon . I know that I am anti HBE positive but i do not know the (critically important) IU/ML for the surface antigen yet.

Thank you all for the support given to others here and I am now joining those ranks. I just hope my condition is not too bad??

[4est]

My understanding of what @studyforhope try to say for you case:

Hepatitis B virus is not destroy the liver cell, liver cell are destroy by our immune system when he try to get out the virus. (ALT is release from the liver during this action)

This destroy of cells causes the fibrosis.

Immune system is believe that is activated by the high viral load numbers

You have been under the treatment and you say that your viral load was low (close to undetectable or 3000 UI max), so for this reason your immune system should not atac the virus and destroy the liver, so no fibrosis (or small fibrosis ) should be detected

this is why @studyforhope considered you case (on the data that you provide) "unusual and worrisome".

So maybe some other factors was the causes for this fibrosis and this is why he as
"Do you have any other risk factors for liver disease like obesity or diabetes or alcohol use or hemochromatosis that could have accelerated the damage? "

[stef2011]

you need to check liver damage by fibroscan

the tests on virus are not correlated to liver damage and most carriers have no damage but only fibroscan can tell, not blood tests
also be aware that it is our immune system to make liver damage and not the virus

[Linda011187]

hello, I am worried about my husbands health, he was diagnosed with hep b since 3 months. His dna test has 8,6x10 (4)  ( 10 in power 4). alt level a bit higher  than normal. Is the dna high ? we havent gone to the doctor yet..I would appreciate any answer from you all..thanks. Linda

[aberdeen577]

Routine blood test for company pension brought this up, I didnt realise I had it and I do not know when I was infected. I wish I did.
I think they put me on combo because I was not achieveing und and I am wondering during all of this time taht, even my VL might have been low, that it was causing this damage.
When I went on tdf in september last year my VL was und bit I dont know about ALT. It remained und each month until Feb this year when it went to 400iu/ml but then went back to und and remains there so far. I am goijg to ask what my ALT was when I started tdf and what it is presently next time I go to clinic.

[aberdeen577]

Why do you say unusual and worrisome? I have no other sides that I know of. I have been taking a fish oil/garlic/seleniumACE/blueberry extract tablets for quite  afew years now unless some of them are having a bad effect on my liver. I also do quite a bit of exercise. And the thing is my doctor never talked to me in any detail about my results; it was always just my lfts are normal and dna is at whatever level. My VL was checked at 6 monthly intervals. But I would never know what the real results were at any time. And, more importantly, until I found this great firum I would not have thought to ask. Do you think that I should not have any fibrosis given the history above and with no other issues to cause damage?

[aberdeen577]

HAve been doing this for years now , just for general health reasons. But I idid read somewhere here where Stef was suggesting fish oil/blueberry/melatonin (I think) as a means to help reduce fibrosis. I am wondering is he still on this regimen as well as the heptech meds.