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Importance of vitamin d levels to help control HBV replication
Hepatology. 2013 May 22. doi: 10.1002/hep.26488. [Epub ahead of print]
Low vitamin D serum concentration is associated with high levels of hepatitis B virus (HBV) replication in chronically infected patients.
Farnik H, Bojunga J, Berger A, Allwinn R, Waidmann O, Kronenberger B, Keppler OT, Zeuzem S, Sarrazin C, Lange CM.
Source
Medizinische Klinik 1, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, Haus 11, 60590 Frankfurt, Germany.
Abstract
Vitamin D is an important immune modulator which plays an emerging role in inflammatory and metabolic liver diseases, including infection with hepatitis C virus (HCV). In contrast, the relationship between vitamin D metabolism and chronic hepatitis B is less well characterized. Therefore, we quantified 25-hydroxyvitamin D [25(OH)D3 ] serum levels in a cohort of 203 treatment-naïve patients with chronic hepatitis B virus (HBV) infection and tested for their association with clinical parameters of chronic hepatitis B. 69 (34%), 95 (47%), and 39 (19%) out of 203 patients had severe vitamin D deficiency [25(OH)D3 <10ng/mL], vitamin D insufficiency [25(OH)D3 ≥10ng/mL and <20ng/mL], or adequate vitamin D serum levels [25(OH)D3 ≥20ng/mL], respectively. In both uni- and multivariate analyses, HBV DNA viral load (log10 IU/mL) was a strong predictor of low 25(OH)D3 serum levels (p=0.0007 and p=0.000048, respectively), and vice versa. Mean 25(OH)D3 serum concentrations in patients with HBV DNA <2000 IU/mL vs. ≥2000 IU/mL were 17 vs. 11 ng/mL, respectively (p<0.00001). In addition, hepatitis B early antigen (HBeAg) positive patients had lower 25(OH)D3 serum levels than HBeAg negative patients (p=0.0013). Finally, 25(OH)D3 and HBV DNA serum levels showed inverse seasonal fluctuations. Conclusions: Low 25(OH)D3 serum levels are associated with high levels of HBV replication in patients with chronic hepatitis B. This represents a major difference to chronic hepatitis C, were numerous previous studies have shown a lacking correlation between HCV viral load vitamin D serum levels. Inverse seasonal fluctuations of 25(OH)D3 and HBV DNA serum levels are suggestive for a functional relationship between both variables. (HEPATOLOGY 2013.).
Copyright © 2013 American Association for the Study of Liver Diseases.
Low vitamin D serum concentration is associated with high levels of hepatitis B virus (HBV) replication in chronically infected patients.
Farnik H, Bojunga J, Berger A, Allwinn R, Waidmann O, Kronenberger B, Keppler OT, Zeuzem S, Sarrazin C, Lange CM.
Source
Medizinische Klinik 1, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, Haus 11, 60590 Frankfurt, Germany.
Abstract
Vitamin D is an important immune modulator which plays an emerging role in inflammatory and metabolic liver diseases, including infection with hepatitis C virus (HCV). In contrast, the relationship between vitamin D metabolism and chronic hepatitis B is less well characterized. Therefore, we quantified 25-hydroxyvitamin D [25(OH)D3 ] serum levels in a cohort of 203 treatment-naïve patients with chronic hepatitis B virus (HBV) infection and tested for their association with clinical parameters of chronic hepatitis B. 69 (34%), 95 (47%), and 39 (19%) out of 203 patients had severe vitamin D deficiency [25(OH)D3 <10ng/mL], vitamin D insufficiency [25(OH)D3 ≥10ng/mL and <20ng/mL], or adequate vitamin D serum levels [25(OH)D3 ≥20ng/mL], respectively. In both uni- and multivariate analyses, HBV DNA viral load (log10 IU/mL) was a strong predictor of low 25(OH)D3 serum levels (p=0.0007 and p=0.000048, respectively), and vice versa. Mean 25(OH)D3 serum concentrations in patients with HBV DNA <2000 IU/mL vs. ≥2000 IU/mL were 17 vs. 11 ng/mL, respectively (p<0.00001). In addition, hepatitis B early antigen (HBeAg) positive patients had lower 25(OH)D3 serum levels than HBeAg negative patients (p=0.0013). Finally, 25(OH)D3 and HBV DNA serum levels showed inverse seasonal fluctuations. Conclusions: Low 25(OH)D3 serum levels are associated with high levels of HBV replication in patients with chronic hepatitis B. This represents a major difference to chronic hepatitis C, were numerous previous studies have shown a lacking correlation between HCV viral load vitamin D serum levels. Inverse seasonal fluctuations of 25(OH)D3 and HBV DNA serum levels are suggestive for a functional relationship between both variables. (HEPATOLOGY 2013.).
Copyright © 2013 American Association for the Study of Liver Diseases.
Look at hiv data. As soon as they start taking high doses of vitamin d and c their viral load falls. It is known. Good doctors will tell you off the record. That oh well high doses of vitamin d are good for you. Search youtube also there is a good info.
"Low 25(OH)D3 serum levels n relation with HBV is a cause or a result ? "
You put up interesting topic. I think that vit d3 deficiency is a result and not a cause, because there was a number of studies about how people become chronic and it is clear that lacking of vit d3 would have been easily spotted but it was not.
I also did not see any study that proves that Vit D3 supplementation has any direct effect on HBV, but d3 defficiency is certainly not good for immune system in general so probably supplementing Vit D3 improves general health and therefore has indirect effect on hbv too.
You put up interesting topic. I think that vit d3 deficiency is a result and not a cause, because there was a number of studies about how people become chronic and it is clear that lacking of vit d3 would have been easily spotted but it was not.
I also did not see any study that proves that Vit D3 supplementation has any direct effect on HBV, but d3 defficiency is certainly not good for immune system in general so probably supplementing Vit D3 improves general health and therefore has indirect effect on hbv too.
nagalase is produced naturally
used wrong words, it is all produced naturally both from viruses, bacteria or cancer cells.....what i meant is nagalase is not pathological when produced at low levels by gut healthy bacteria or in pregnancy
used wrong words, it is all produced naturally both from viruses, bacteria or cancer cells.....what i meant is nagalase is not pathological when produced at low levels by gut healthy bacteria or in pregnancy
nagalase can be decreased by probiotic gcmaf or injectable gcmaf only or removing the source of it
nagalase is produced naturally only by pregnant women to avoid fetus rejection and by our healthy bacteria in the gut (but at very low levels less than 0.6nmol/mg) to escape our immune system detection
clearing nagalase from our blood means improved immune function but not hbv clearance and also nagalase levels in blood are much less than levels in the liver for sure
nagalase is produced naturally only by pregnant women to avoid fetus rejection and by our healthy bacteria in the gut (but at very low levels less than 0.6nmol/mg) to escape our immune system detection
clearing nagalase from our blood means improved immune function but not hbv clearance and also nagalase levels in blood are much less than levels in the liver for sure
how would be it ? if we all members do a survey within ourselves about vit d levels and ours hbvdna or hbsag ,before and after vit d suppliments. that would be nice to give a hint about "vit d effect",may be a seperate post.
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