Aa
A
A
Close
Avatar universal
Increased serum Phosphorus
I'm a CHB, on  etv and tdf combo since for 18 months , this is the first time to have an increase in serum phosphurs about 7.7 mg/dl (Normal 2.3 to 4.7) as well decreased eGFR about 70 ..

I am 27 years old ..

your suggestions ?
Cancel
10 Answers
Page 1 of 1
Avatar universal
start use of fibroguard

check that vitd is above 50ng/ml if not start supplementation of d3 and k2

as to egfr tests use creatinine clearance by 24hrs urine collection, the other tests that use formulas are not so reliable.also albumine/microalbumine ratio can be a useful test
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Submit Comment
Avatar universal
recheck after 4 weeks all these tests if improved

my experience is my creatinine went from 1.2 to 0.7-0.8, creatinine clearance from about 108 to about 120
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Submit Comment
Avatar universal
thx stef , but what do you think about this increase ? why this inctreased in only one month ? as well in one month egfr decreased fro 120 to 70 ??
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Submit Comment
Avatar universal
sorry i have no idea but i do know that only creatinine clearance by 24hrs urine collection is realiable, formulas from blood creatinine values are useless because you can have kidneys damage and normal creatinine

i monitor my kidneys by:
creatinine clearance by 24hrs urine collection once a year
blood creratinine every 3 months
blood  Phosphorus every 3 months
blood calcium every 3 months

checked creatinine/microalbumine ratio once in 3 years

i prevent damage by fibroguard and keeping urine ph around 7 and when lowers to 6 or 6.5 i increase by baking soda
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Submit Comment
Avatar universal
thx stef , ok with my above results do I have kidney damage ? can this be regressed ?
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Submit Comment
Avatar universal

very difficult to say if you have kidneys damage, there are no test with sensibility high enough.study for hope posted some tests not easy to find commercially with good sensibility but don t remember all of them.

creat clearance by 24hrs urine collection as a minimum to know if you have a decline in function

also what is your blood creatinine before starting nucs and kinects under nucs

did you test creatinine microalbumine ratio?this is the test studyforhope suggested to predict damage, it gets abnormal before damage is done
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Submit Comment
Avatar universal
thx stef , actually I didn't test creatinine before , always I tested eGFR and serum phosphors , I'll try to test as you mentioned ..

Thx again
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Submit Comment
Avatar universal
http://apasl.meetingxpert.net/APASL_796/poster_64119/program.aspx

tdf+telbivudine combo can be interesting too in case of kidneys problems
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Submit Comment
Avatar universal
tdf can actually cause low phosphorus levels - hypophosphatemia
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Submit Comment
Avatar universal
the interesting is that adding telbivudine even adefovir or truvada which are very toxic for kidneys recover kidneys function and drugs become non toxic

if you dont recover by fibroguard and baking soda you may consider changing entecavir with telbivudine, the potency of this combo is higher than entecavir and barrier to resistance as good as with entecavir
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Submit Comment
Your Answer
Avatar universal
Answer
Know how to answer? Tap here to leave your answer...
Answer
Submit Answer
A
A
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Hepatitis B Community Resources
RSS Expert Activity
233488 tn?1310696703
Blank
Marathon Running Done Over Many Yea...
05/15 by John C Hagan III, MD, FACS, FAAOBlank
233488 tn?1310696703
Blank
New Article on Multifocal IOL vs &q...
05/15 by John C Hagan III, MD, FACS, FAAOBlank
748543 tn?1463449675
Blank
TMJ/TMJ The Connection Between Teet...
01/15 by Hamidreza Nassery , DMD, FICOI, FAGD, FICCMOBlank
Top Hepatitis Answerers