Aa
A
A
Close
Avatar_universal
Indication for my lab's results
hi
iv just got my results as below:
HBsAG : positive
Anti-HBs : Negative
Anti-HBc :positive
HBV-DNA(PCR): positive
Also my SGOT(AST) is 40 & SGPT(ALT) is 62
My Question is that what treatments should i consider for this status?
THNX
Cancel
7 Answers
Page 1 of 1
Avatar_universal

all useless tests

cronic hbv infections need quantitative antigenes, especially hbsag in iu/ml and hbvdna in iu/ml

fibroscan is essential to see liver damage, no other test except biopsy can see it.without these tests it is useless to consider and treatment or making blood tests, hbv patients can t be monitored unless those tests are performed, all other tests are useless without these ones
Comment
Cancel
Avatar_universal
Comment
Comment
Submit Comment
Avatar_universal
Allright thnx for your asist but unfortunately this was the best place that could have been tested in our country,and we see that it has no quantity,but generally is there any pills or something to reduce the quantity to negative? or to the lowest measure? im not professional in medic so i need these informations to know about my disease.
Comment
Cancel
Avatar_universal
Comment
Comment
Submit Comment
Avatar_universal

making hbvdna by tenofovir for about 1-2 years and then add-on of interferon clears hbv.
40% clear hbsag in 48weeks and the rest gets it very low so they will continue to clear until 96week of combo tdf+interferon

my guess is almost 100% can go on to clear hbv by continuous tenofovir therapy and periodic add on of interferon 96weeks, i mean if there is no response in 96weeks of this combo tdf must be kept and interferon can be retried many times during the years
Comment
Cancel
Avatar_universal
Comment
Comment
Submit Comment
Avatar_universal
would u mind if you explain more about interferon & tenofovir therapy? i couldnt get you
Comment
Cancel
Avatar_universal
Comment
Comment
Submit Comment
Avatar_universal
http://www.medhelp.org/posts/Hepatitis-B/Add--on-interferon-to-a-stable-nucleoside--hbsag-loss-40-full-poster/show/1636802

data is all here, the result of 40% clearance by 48weeks was on weaker nucs than tenofovir so it is even possible to get higher than 40%
Comment
Cancel
Avatar_universal
Comment
Comment
Submit Comment
Avatar_universal

gilead has had a trial without prior use on nucs, so directly interferon+tenofovir 48weeks with hbsag loss in 26%, so results were weaker wthout hbvdna prior to interferon start

the big trials, >1000 patients, will start 2012 so you will have final results and probably higher percentages by 2013-2014

about previous poster at san francisco 2011
guy on etv 3 years and then etv+interferon
hbsag 7800iu/ml after interferon add-on 48weeks 30iu/ml, when hbsag is at this low level hbsag is almost 100% certain
Comment
Cancel
Avatar_universal
Comment
Comment
Submit Comment
Avatar_universal

sorry corrected
gilead has had a trial without prior use on nucs, so directly interferon+tenofovir 48weeks with hbsag loss in 26%, so results were weaker wthout hbvdna undtetactable prior to interferon start
Comment
Cancel
Avatar_universal
Comment
Comment
Submit Comment
Your Answer
Avatar_universal
Answer
Know how to answer? Tap here to leave your answer...
Answer
Indication for my lab's results
Submit Answer
A
A
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Hepatitis B Community Resources
RSS Expert Activity
233488_tn?1310696703
Blank
Marathon Running Done Over Many Yea...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
233488_tn?1310696703
Blank
New Article on Multifocal IOL vs &q...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
748543_tn?1443740527
Blank
TMJ/TMJ The Connection Between Teet...
01/15 by Hamidreza Nassery , DMD, FICOI, FAGD, FICCMOBlank
Top Hepatitis Answerers
Avatar_m_tn
Blank
stef2011
Italy
Avatar_m_tn
Blank
StephenCastlecrag
Australia
Avatar_m_tn
Blank
sorte
Poland
Avatar_m_tn
Blank
Jatashankar
India
Avatar_m_tn
Blank
March06
Other
Avatar_f_tn
Blank
twinboys1girl4me