The greatest decline on interferon usually happens in first 3 months....but its not rule of thumb....
One would wish to get his/her hbsag bellow 1000, then he/she would have chance of clearing it and reducing chances for cancer....
How old and what genotype are you?
Hi stef,
HBsAg Quantitative(CMIA)
26/12/14 - 34268 IU/ml
20/02/15 - 16066 IU/ml
03/03/15 - 27602 IU/ml (peg intf Started)
08/04/15 - 31029.85IU/ml
07/05/15 - 29542.08IU/ml
03/06/15 - 12131.10 IU/ml (3 months on peg)
01/7/15 - 7584 IU/ml
27/7/15- 10230 IU/ml
16/9/15 - 8950 IU/ml (6 months on peg)
I could see a drastic decrease for 3 months on peg, but for next 3 months there isn't much of a decrease in hbsag levels, I want to understand how peg intf works with hbsag.
Imran
That is not true. I ran my genotype and I have both those mutations pc and bc mutations g1896a and c1858t plus a1762T and G1764a and I am genotype c
I am not aware of any special meaning of this precore mutation combo in genotype A. There might be, but i have not read about it.
Hi studyforhope,
There is a question that I've been wanting to ask you for years. My wife has two precore mutations: G1896A and C1858T. As I was reading some journals I read that both of these mutations paired together can only happen in Genotype A?
Is that correct or do you have any insight on it. She is from South Asia.
Thanks!
no it was seen only on sequential peg add on in italy by lampertico and hermes
both studies achieved a good decline of hbsag vs mono but not better hbsag loss percentages.hermes is still going
If yes that log 0.5 log decrese rule doesn't apply.
on genotype D hbeag neg it is best to use 24weeks, on peg add on hermes study they waited 24 weeks before stopping non responders