Low vitamin D levels prevalent in untreated patients with HBV

[sorte]

http://www.healio.com/hepatology/chronic-hepatitis/news/online/%7B7d927cfe-6bb5-4d9e-81d6-11eed5001e71%7D/low-vitamin-d-levels-prevalent-in-untreated-patients-with-hbv

[sorte]

"Low baseline vitamin D level was associated with lower baseline ALT level and a lower tendency to normalize ALT after 48 weeks of treatment"

Not sure how to interpret it. Low vit D = low immune response so ALT is not rising with it's all good and bad consequences ?

[Jatashankar]

Sorte u ve pretty fair rise in alt. do u want more rise?
That might b harmful but still hope well for u

[Jatashankar]

This thing is correct low immune low alt

[stef2011]

these results make me think that hbv lowers vitamin d to lower immune response or damaged livers impair vitamin d pathways and lower immune response too

so directly or indirectly hbv impairs vitamin d pathways

[Jatashankar]

Nice info Steff, is it really possible for the immune system to cleave the integrated cccdna from host dna without any damage to cells. In such condition only hbsag decline will b the response indicator or any other marker or phenomena. My alt has almost normalised.

[sorte]

nono, I don't want more rise and my doctor doesn't want it too :) I just posted this as a question cuz I don't fully understand that relation between d3 and ALT.
Only thing we know now is that decent d3 level is strong factor in natural seroclearance.

[stef2011]

did you have your vitd25oh and intact pth checked?i only got peg response when adding gcmaf and intact pth less than 20pg/ml