HBV silent carrier infected with HDV

[drdean123]

I m  HBV carrier  since my childhood  , never had any symptoms, I  have Hepatitus e Ag =nonreactive, PCR viral load is undetectable ,all time had  normal SGPT but,  recently 1 week before i had  slightly raised SGPT that was 46 so  my Dr. adviced me to do  Hepatitus D Antibodies test which came to be +ve,    I  m very worried now a days, I  dont have any symptoms  but   HBV with HDV is terrible diagnosis   ,please give me some  useful advices  should i start treatment  ,will it be helpful for me   or wait for DEATH.  & LIVER FAILURE

[drdean123]

thanx stef2011 ,ix str, thanx a lot your words gave me life,i  m v. depressed now a days because  of this,  i m currently assymptomatic , my  Hep. B DNA  is less than 2500 copies &  undetectable  on  quantitative  analysis, should i start treatment??

[stef2011]

it's different to testing positive to HDV surface antigen....

hdv is not a virus, it is a hbv parassite, it uses hbsag antigen from hbv, it doesn t have a surface antigen

it does have to be worried but as long as he monitors liver by fibroscan and takes antioxidants or hepatitistechnologies products it wont develop liver damage

hdv is a plants virus he can infect only people infected by hbv (those with lmivudine mutants have mutated hbsag so they can t be infected by hdv).it can infect humans because it uses hbsag antigen as coat and infect human cells

as long as hbsag is positive hdv will stay, it doesn t matter antibodies, it can be monitored by hdvrna quantity but this is not useful to quantify virus perfectly an hbsag quantitative test is better

[lxstr]

I am not sure if you need to be this worried. Testing positive to HDV Antibodies means you have antibody to HDV, it's different to testing positive to HDV surface antigen.

[OrientS]

Is Truvada launched in the market?

Is more potent than Viread because both produced by same company?

[stef2011]

check hepatitstechnologies products, todd had cirhosis due to hbv+hcv and reversed cirrhosis totally from 2004 to now, so whatever happens you can block all liver damage especially if your liver has much less damage than cirrhosis

make sure you have acess to a fibroscan because this is the only tool to monitor liver damage.biopsy is not goo because it can be done every 6months and can understimate damage

as to treatments all those that clear hbv clear hdv too (hdv uses hbsag to infect humans, even a change of hbsag due to lam can clear hdv, but better try the no mutations road....)

rep9ac clears hbsag within weeks, still experimental but send an email if you can be a candidate of the next human trials (they did 1 or 2 small ones)

myracludex, experimental in germany, no news on human trials

alinia, might lower hbsag and so weaken hdv.it is very good in combo with interferon

there is a case report about clearing hbv+hdv in 11months by interferon+truvada, it was hbeag postive at start of treatment

my suggestion:
interferon+tenofovir is already the standard for hbv+hdv and we know now that interferon clears hbv when hbsag less than 1500iu/ml and hbvdna very low or undetactable, so check your hbsag with abbott architect, the unit must be iu/ml otherwise it is not architect and it is not quantitative
i'd add inf+tenofovir+alinia+simvastatin because we also know that both low cholesterol and alinia will increase response to interferon and so possibility of clearance

check your vitamin d 25oh, it must be higher than 50ng/ml because we also know there is inverse correlation between vit d level and hbvdna, the best serum ranges are:
vit d 25oh 50-80ng/ml
tot chol less than 150
ldl less than 80
hdl more than 50 (the higher the better it has an antiviral effect)

[drdean123]

please reply me.i m v.depressed ..........feeling to die