Aa
Normal vit D levels are associated with hbsag seroclearance.
Normal vitamin D levels are associated with spontaneous hepatitis B surface antigen seroclearance.
Mahamid M, Nseir W, Abu Elhija O, Shteingart S, Mahamid A, Smamra M, Koslowsky B.
Source
Mahmud Mahamid, Shimon Shteingart, Mosab Smamra, Benjamin Koslowsky, Digestive Disease Institute, Shaare Zedek Medical Center, Jerusalem 93722, Israel.
Abstract
AIM:
To investigate a possible association between serum vitamin D levels and spontaneous hepatitis B surface antigen (HBsAg) seroclearance.
METHODS:
Fifty-three patients diagnosed with chronic inactive hepatitis B and spontaneous HBsAg seroclearance were followed up in two Israeli liver units between 2007 and 2012. This retrospective study reviewed medical charts of all the patients, extracting demographic, serological and vitamin D rates in the serum, as well as medical conditions and current medical therapy. Spontaneous HBsAg seroclearance was defined as the loss of serum HBsAg indefinitely. Vitamin D levels were compared to all patients who underwent spontaneous HBsAg seroclearance.
RESULTS:
Out of the 53 patients who underwent hepatitis B antigen seroclearance, 44 patients (83%) had normal levels of 25-hydroxyvitamin vitamin D compared to 9 patients (17%) who had below normal levels. Multivariate analysis showed that age (> 35 years) OR = 1.7 (95%CI: 1.25-2.8, P = 0.05), serum vitamin D levels (> 20 ng/mL) OR = 2.6 (95%CI: 2.4-3.2, P = 0.02), hepatitis B e antigen negativity OR = 2.1 (95%CI: 2.2-3.1, P = 0.02), low viral load (hepatitis B virus DNA 8 years) OR = 1.6 (95%CI: 1.15-2.6, P = 0.04) were also associated with spontaneous HBsAg seroclearance.
CONCLUSION:
We found a strong correlation between normal vitamin D levels and spontaneous HBsAg seroclearance.
Mahamid M, Nseir W, Abu Elhija O, Shteingart S, Mahamid A, Smamra M, Koslowsky B.
Source
Mahmud Mahamid, Shimon Shteingart, Mosab Smamra, Benjamin Koslowsky, Digestive Disease Institute, Shaare Zedek Medical Center, Jerusalem 93722, Israel.
Abstract
AIM:
To investigate a possible association between serum vitamin D levels and spontaneous hepatitis B surface antigen (HBsAg) seroclearance.
METHODS:
Fifty-three patients diagnosed with chronic inactive hepatitis B and spontaneous HBsAg seroclearance were followed up in two Israeli liver units between 2007 and 2012. This retrospective study reviewed medical charts of all the patients, extracting demographic, serological and vitamin D rates in the serum, as well as medical conditions and current medical therapy. Spontaneous HBsAg seroclearance was defined as the loss of serum HBsAg indefinitely. Vitamin D levels were compared to all patients who underwent spontaneous HBsAg seroclearance.
RESULTS:
Out of the 53 patients who underwent hepatitis B antigen seroclearance, 44 patients (83%) had normal levels of 25-hydroxyvitamin vitamin D compared to 9 patients (17%) who had below normal levels. Multivariate analysis showed that age (> 35 years) OR = 1.7 (95%CI: 1.25-2.8, P = 0.05), serum vitamin D levels (> 20 ng/mL) OR = 2.6 (95%CI: 2.4-3.2, P = 0.02), hepatitis B e antigen negativity OR = 2.1 (95%CI: 2.2-3.1, P = 0.02), low viral load (hepatitis B virus DNA 8 years) OR = 1.6 (95%CI: 1.15-2.6, P = 0.04) were also associated with spontaneous HBsAg seroclearance.
CONCLUSION:
We found a strong correlation between normal vitamin D levels and spontaneous HBsAg seroclearance.
Best Answer
To my understanding/experience (does not mean I am right) is like this:
I have a low Na/k ratio (1.2) (yours is 30/33 = +-1)...normally should be 2.5, but for chronically disease people is lower.
When I take high D3, I assume renin lowers because 1.25 gets higher, based on this: http://www.ncbi.nlm.nih.gov/pubmed/12122115 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system.). I did not really do the renin test. low renin ->low NA/K ratio: http://circ.ahajournals.org/content/39/5/685
Is your 1.25 level always high and it gets higher when you take D3? ...this is expected for chronically disease people (immune system detects pathogens and converts all D3 in 1.25 in order to activate VDR and defend the body) and correlates with the fact that high 1.25 lowers Na/K ratio (vitality ratio). I will try to lower 1.25 (by taking a VDR agonist, the body does not need to increase 1.25 in order to activate the VDR so 1.25 should get lower (like normal healthy people have)) to see what happens to NA/K, according to my ideas it should rise up (like healthy people have).
I have a low Na/k ratio (1.2) (yours is 30/33 = +-1)...normally should be 2.5, but for chronically disease people is lower.
When I take high D3, I assume renin lowers because 1.25 gets higher, based on this: http://www.ncbi.nlm.nih.gov/pubmed/12122115 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system.). I did not really do the renin test. low renin ->low NA/K ratio: http://circ.ahajournals.org/content/39/5/685
Is your 1.25 level always high and it gets higher when you take D3? ...this is expected for chronically disease people (immune system detects pathogens and converts all D3 in 1.25 in order to activate VDR and defend the body) and correlates with the fact that high 1.25 lowers Na/K ratio (vitality ratio). I will try to lower 1.25 (by taking a VDR agonist, the body does not need to increase 1.25 in order to activate the VDR so 1.25 should get lower (like normal healthy people have)) to see what happens to NA/K, according to my ideas it should rise up (like healthy people have).
What are your results?
Actually my Na/K ration doeston correlate with Vit D at all. It is around 30-33 for years. Though I have never checked renin.
Actually my Na/K ration doeston correlate with Vit D at all. It is around 30-33 for years. Though I have never checked renin.
"I also tested 1,25(OH) and it is interesting that it is 82 pg/ml that is 40% above upper reference range. That is unusual for 25(OH) insufficiency. In fact many researches show that 1,25(OH) is not elevated even when 25(OH) reaches 150 ng/ml."
In chronic disease, the body tries to activate to VDR in order to kill the pathogens, that is why 1,25 is elevated. And pathogens block the VDR in order to survive in our bodies. This is a known chronic disease paradox: low 25 with high 1,25. check mpkb.org to understand.
Very high D3 does not make much sense to me, maybe 10 times less gcmaf with a low dose VDR agonist (according to gcmaf paper, this way gcmaf will be affordable to anybody) will work together and let the body heal itself (over a long period of time)...this way one avoids the high dose VDR agonist ( recommended on the MP) and also the high gcmaf price. But will it really work?
In my case, high D3 leads to even more 1.25 which lowers renin -> low na/k ratio(low vitality, exactly the opposite of healing).
Did people taking high D3 measure their Na and K?...this are very inexpensive tests, to see if it correlates with my results.
In chronic disease, the body tries to activate to VDR in order to kill the pathogens, that is why 1,25 is elevated. And pathogens block the VDR in order to survive in our bodies. This is a known chronic disease paradox: low 25 with high 1,25. check mpkb.org to understand.
Very high D3 does not make much sense to me, maybe 10 times less gcmaf with a low dose VDR agonist (according to gcmaf paper, this way gcmaf will be affordable to anybody) will work together and let the body heal itself (over a long period of time)...this way one avoids the high dose VDR agonist ( recommended on the MP) and also the high gcmaf price. But will it really work?
In my case, high D3 leads to even more 1.25 which lowers renin -> low na/k ratio(low vitality, exactly the opposite of healing).
Did people taking high D3 measure their Na and K?...this are very inexpensive tests, to see if it correlates with my results.
no not now
Stef, are you taking heptech?
11th of november always 50.000iu daily, i m using biotech pill that has 50.000iu
before nov 11th i was using 5000iu pills from d3plus from biotech to a total of 40.000iu daily, but some weeks i took 60.000 or 80.000iu when test results were low
before the 4th of sept i was taking about 20.000-25.000iu daily
before nov 11th i was using 5000iu pills from d3plus from biotech to a total of 40.000iu daily, but some weeks i took 60.000 or 80.000iu when test results were low
before the 4th of sept i was taking about 20.000-25.000iu daily
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