Normal vit D levels are associated with hbsag seroclearance.

[Rome70]

Normal vitamin D levels are associated with spontaneous hepatitis B surface antigen seroclearance.
Mahamid M, Nseir W, Abu Elhija O, Shteingart S, Mahamid A, Smamra M, Koslowsky B.
Source
Mahmud Mahamid, Shimon Shteingart, Mosab Smamra, Benjamin Koslowsky, Digestive Disease Institute, Shaare Zedek Medical Center, Jerusalem 93722, Israel.
Abstract
AIM:
To investigate a possible association between serum vitamin D levels and spontaneous hepatitis B surface antigen (HBsAg) seroclearance.
METHODS:
Fifty-three patients diagnosed with chronic inactive hepatitis B and spontaneous HBsAg seroclearance were followed up in two Israeli liver units between 2007 and 2012. This retrospective study reviewed medical charts of all the patients, extracting demographic, serological and vitamin D rates in the serum, as well as medical conditions and current medical therapy. Spontaneous HBsAg seroclearance was defined as the loss of serum HBsAg indefinitely. Vitamin D levels were compared to all patients who underwent spontaneous HBsAg seroclearance.
RESULTS:
Out of the 53 patients who underwent hepatitis B antigen seroclearance, 44 patients (83%) had normal levels of 25-hydroxyvitamin vitamin D compared to 9 patients (17%) who had below normal levels. Multivariate analysis showed that age (> 35 years) OR = 1.7 (95%CI: 1.25-2.8, P = 0.05), serum vitamin D levels (> 20 ng/mL) OR = 2.6 (95%CI: 2.4-3.2, P = 0.02), hepatitis B e antigen negativity OR = 2.1 (95%CI: 2.2-3.1, P = 0.02), low viral load (hepatitis B virus DNA  8 years) OR = 1.6 (95%CI: 1.15-2.6, P = 0.04) were also associated with spontaneous HBsAg seroclearance.
CONCLUSION:
We found a strong correlation between normal vitamin D levels and spontaneous HBsAg seroclearance.

[stef2011]

wanted to update my sisters hbsag decline on tenofofvir and vitamin d3 10.000iu daily (sometimes a little more when she is sick)

baseline 2012 from 18.000 to 21.000iu/ml
started vit d supplementation in 2011
before tdf dec 2013 about 13.000iu/ml
end of 2014 9000iu/ml
2015 8000iu/ml
jun 17 2016 5000iu/ml

[joc2011]

Great. very good decline on just TDF and Vit D 10k. Great results. Will she switch to TAF when it becomes available?

[joc2011]

Great. very good decline on just TDF and Vit D 10k. Great results. Will she switch to TAF when it becomes available? Any plans to add INF?

[stef2011]

with such low dose i take 200mcg but also 90mcg is ok

an expert doctor on coimbra protocol suggested 600mcg for 50.000-100.000iu doses

vit d3 needs magnesium, vit a but low max 3000iu daily, vit k2 mk7, none of these have sides unless there is a deficiency among these or the brand has rancid oil or emulsions with vit d

try to supplement 400mg of magnesium daily, i use drbest which has a type of mg easily absorbed, i dont remember its name

[Elijah256]

How much vitamin k2 mk7 would you take with 10000-15000 iu vitamin d? It seems like vitamin k2 mk7 makes my eye twitch and gives me a sickest feeling. I take 100 daily. I was trying to take 200-300 a day but couldn't handle it.

[stef2011]

update on my use of vitamin d:

because of the issues with creatinine, i also checked my pth and it had gone to 5pg/ml (norm 10-80) too low, so i lowered my dose to 100.000iu daily, then to 50.000iu, then 40.000iu and then stopped for 3weeks

then i restarted with 15.000-20.000iu daily which looks enough to keep pth 17pg/ml, i added also vit A (not in betacarotene type), creatinine is now 0.68 (norm 0.6-1.3)

the fact that now i need normal vit d levels to lower pth means that now my vdr receptor is working different and much better.i dont know if this reflects a new balance with hbsag since i dont have yet results

[peacefulife]

Thank you

[stef2011]

it was posted on another thread, should be on the market in cuba by this year and south america next year.
combo with nucs or peg should help immune system clear hbv, they have not published hbsag quant data so difficult to say how much it can help