Normal vit D levels are associated with hbsag seroclearance.

[Rome70]

Normal vitamin D levels are associated with spontaneous hepatitis B surface antigen seroclearance.
Mahamid M, Nseir W, Abu Elhija O, Shteingart S, Mahamid A, Smamra M, Koslowsky B.
Source
Mahmud Mahamid, Shimon Shteingart, Mosab Smamra, Benjamin Koslowsky, Digestive Disease Institute, Shaare Zedek Medical Center, Jerusalem 93722, Israel.
Abstract
AIM:
To investigate a possible association between serum vitamin D levels and spontaneous hepatitis B surface antigen (HBsAg) seroclearance.
METHODS:
Fifty-three patients diagnosed with chronic inactive hepatitis B and spontaneous HBsAg seroclearance were followed up in two Israeli liver units between 2007 and 2012. This retrospective study reviewed medical charts of all the patients, extracting demographic, serological and vitamin D rates in the serum, as well as medical conditions and current medical therapy. Spontaneous HBsAg seroclearance was defined as the loss of serum HBsAg indefinitely. Vitamin D levels were compared to all patients who underwent spontaneous HBsAg seroclearance.
RESULTS:
Out of the 53 patients who underwent hepatitis B antigen seroclearance, 44 patients (83%) had normal levels of 25-hydroxyvitamin vitamin D compared to 9 patients (17%) who had below normal levels. Multivariate analysis showed that age (> 35 years) OR = 1.7 (95%CI: 1.25-2.8, P = 0.05), serum vitamin D levels (> 20 ng/mL) OR = 2.6 (95%CI: 2.4-3.2, P = 0.02), hepatitis B e antigen negativity OR = 2.1 (95%CI: 2.2-3.1, P = 0.02), low viral load (hepatitis B virus DNA  8 years) OR = 1.6 (95%CI: 1.15-2.6, P = 0.04) were also associated with spontaneous HBsAg seroclearance.
CONCLUSION:
We found a strong correlation between normal vitamin D levels and spontaneous HBsAg seroclearance.

[joc2011]

How much Vit D does she take daily? 10,000 iu??

[mer971]

Thanks for the update

[Bnd11]

Thank you for the answer.
In this case the results are even more impressive. :)

[stef2011]

negative

[Bnd11]

very good, impressive results :)

What is your sister's HBeAg status?

[stef2011]

my sister's experience:
vitd25oh>100ng/ml from sept 2013
oct 2013 150ng/ml
dec 2014 103ng/ml
apr 2014  108ng/ml

used gcmaf for about 2 months before starting tdf and then stopped when started tdf

baseline: hbsag 13700iu/ml, hbvdna 1.600.000iu/ml
dec 2013 tdf+vit d3
13 jan 2014 hbvdna 490iu/ml
08 apr 2014 hbsag 9000iu/ml, hbvdna und
19 may 2014 hbsag 7000iu/ml, hbvdna und

hbsag keeps going down, vitamind25oh is kept 100-150ng/ml, calcium stays low, pth doesn t go down but stays stable at mid normal levels