Sudden Increase in ALT/AST after stopping Ntz and LIv 52 HB increases HbsAg

[smile_boy]

Hi Stef and Others,

There is a sudden increase in my AST and ALT values after stopping Ntz. I stopped Ntz in August 2011 end and later I started taking Liv52 HB.

Results on Feb-2012:-
ASPARTATE AMINOTRANSFERASE (SGOT )PHOTOMETRY =98.00 U/l M: 0 to 37 - F: 0 to 31
ALANINE TRANSAMINASE (SGPT) PHOTOMETRY = 244.00 U/l M: 0 to 37 - F: 0 to 31

ALKALINE PHOSPHATASE PHOTOMETRY =98.30 U/l M:53 to 128 - F:42 to 98
BILIRUBIN -DIRECT PHOTOMETRY =0.26 mg/dl 0 - 0.3
BILIRUBIN - TOTAL PHOTOMETRY= 0.85 mg/dl 0 - 1.2
BILIRUBIN (INDIRECT) CALCULATED =0.59 mg/dl 0 - 0.9
GAMMA GLUTAMYL TRANSFERASE (GGT)PHOTOMETRY =21.00 U/l M: 0 to 50 - F :0 to 30
PROTEIN - TOTAL PHOTOMETRY =8.30 gm/dl 6.0 - 8.3
ALBUMIN - SERUM PHOTOMETRY= 4.56 gm/dl 3.2 - 5.0
SERUM ALBUMIN/GLOBULIN RATIO CALCULATED =1.22 Ratio 0.9 - 2.0
25-OH VITAMIN D TOTAL= 37.26 ng/ml
HbsAg Quant - 1789 iu/ml



Results on Aug -2011:-
SGOT - 25.90
SGPT - 38.90
HbsAG - 733 iu/ml

Almost SGPT has increased 10 times. Kindly help me. I'm very scared about my situation. If stopping ntz increases ALT ans AST ,we cannot take ntz for life long? please help

[smile_boy]

Thanks for the reply. I would consider taking biopsy . Fibroscan is bit difficult to take. Also I will meet doctor immediately. Do you have any idea of my Iron Conent. It is increased

[smile_boy]

Hi Stef,

I would check QHbsAg and DNA. Constantly my ALT/AST has been in high range . Hope you remember this. What I should do now? Should I wait for fibroscan?

Also iron content is more . is it indication of cirohosis?

[stef2011]

remember that we posted in the past all indian generic brands for tenofovir and there was one brand just 21usd per month

also do not skip the vitamin d suggestion since it helps with fibrosis and immune system

[StephenCastlecrag]

I do not know how to interpret your LFT results. My concerns, just as studyforhope pointed out previously, are that you have many ALT flares for the last two years. Therefore it is important to know the state of your liver, either from a Fibroscan (mindful of what stef2011said) or a biopsy. You should seriously consider treatment.

[stef2011]

you have to check for hbsag quant and fibroscan at least, also hbvdna should be done

liver damage is now a possibility so you d best check fibroscan and then start tenofovir if there is damage.remember that fibroscan is increased if alt were more than 200, in this case you need to wait few months before fibroscan is very reliable

[smile_boy]

Also Iron content of my blood is more

IRON :- 219 μg/dl ( Normal Range : Male : 70 - 180)

TOTAL IRON BINDING CAPACITY (TIBC) : 358.7 μg/dl  Normal Range : Male: 225 - 535 μg/dl

% TRANSFERRIN SATURATION : 61.05% Normal Range 13 - 45.

Is there indication of Cirrhosis? Can you please help me on this?