What Does the HepB-AntiHBc (IgG and IgM) MEI test for?

[remix99]

Hi I just wondering what the  HepB-AntiHBc (IgG and IgM) MEIA  - NonReactive means? Thank you for your time.

[zellyf]

No problem.  I think this post was split into two different threads which also made it a little confusing.

[stevenNYer]

That's the problem when you just asked about just one marker.  I was under the impression that you are surface antigen positive (have HepB)...you do not.  In this case, your IgM anti-HBc is of course non-reactive.  Your immune system didn't have to develop such antibody since you didn't have that corresponding antigen in your system.

Zelly:  Thanks for picking that one up.

[zellyf]

I'm not sure I know your question.  Do you feel you haven't been vaccinated?

IgM antibody subclass of anti-HBc.  Positivity indicates recent infection with HBV (<6 mos). Its presence indicates acute infection.

IgG antibody subclass of anti-HBc is a marker of past or current infection with HBV. If it and HBsAg are both positive (in the absence of IgM anti-HBc), this indicates chronic HBV infection.

As far as I can tell you have been vaccinated and there is no indication of previous infection.  Live long and prosper.

[remix99]

The HBcAb is an antibody that is part of the virus- it does not provide protection. A "positive" or "reactive" HBcAb (or anti-HBc) test result indicates a past or present infection, but it could also be a false positive. The interpretation of this test result depends on the results of the other two tests. Its appearance with the protective surface antibody (positive HBsAb or anti-HBs) indicates prior infection and recovery. For chronically infected persons, it will usually appear with the virus (positive HBsAg).These are my results.



Test                                                                     Result
HepB-HBsAg CMIA                                                  NonReactive
HepB-AntiHBs MEIA                                                Reactive 183.60mIU/ml
HepB-AntiHBc (IgG and IgM) MEIA                           NonReactive

[remix99]

I dont get it..I just got my full panel results interpreted and they said no sign of previous infection and that ive been vaccinated..

[stevenNYer]

IgM anti-HBc NonReactive is indicative of an chronic HepB infection.  

IgM anti-HBc is produced by your immune system early on of an acute infection.   So when it's no longer "reactive", it usually is a chronic infection.