Aa
first evidence nucs clear hbsag
http://www.congressosimit.it/wp-content/uploads/simitPDF/Santa_Maria/29%20Ottobre%202013/02.%20Comunicazioni%20Orali/01.%20Elisabetta%20Teti/presentazione.pdf
Clearance of hbv in about 10years of lamivudine, it is 5 patients in italian, tenofovir will sure do much better
4 patients achieve very low hbsag which reflects reconstitution of t cell responses, 1 patient did not achieve low hbsag and doesn t clear hbsag
the 4 patients stop lam and clear hbsag and hbvdna
of course these patients had no lam resistance so hbvdna suppression was kept for 10 years.this example shows that nucs are able to clear hbv infection and that they are essential to t cell recovery, pegimterferon add on after 5 years of nucs will shorten time to clear hbsag for sure
tenofovir is reported to take 17years to clear hbsag according to data on hbsag decline, this time is probably shorter.
Clearance of hbv in about 10years of lamivudine, it is 5 patients in italian, tenofovir will sure do much better
4 patients achieve very low hbsag which reflects reconstitution of t cell responses, 1 patient did not achieve low hbsag and doesn t clear hbsag
the 4 patients stop lam and clear hbsag and hbvdna
of course these patients had no lam resistance so hbvdna suppression was kept for 10 years.this example shows that nucs are able to clear hbv infection and that they are essential to t cell recovery, pegimterferon add on after 5 years of nucs will shorten time to clear hbsag for sure
tenofovir is reported to take 17years to clear hbsag according to data on hbsag decline, this time is probably shorter.
research on sim and apoptosis is particular:
it prevents apoptosis on healthy cells but increases apoptosis on cancer cells, i can t find nothing on infected cells though
it prevents apoptosis on healthy cells but increases apoptosis on cancer cells, i can t find nothing on infected cells though
i think simvastatin can help with this more than alcool, sim is reported to increase apoptosis and prevent HCC too
i remember a memeber here posted about his tenofovir therapy plus simvastatin which was started before hbv therapy.his hbsag was very low at something like 5 years or less.we should collect more memebers on this combo
i remember a memeber here posted about his tenofovir therapy plus simvastatin which was started before hbv therapy.his hbsag was very low at something like 5 years or less.we should collect more memebers on this combo
I can understand why no baseline qHbsAg data was collected.
Most of the 5 patients have relatively low qHBsAg at pre-suspension. So why are antivirals able to gradually bring down qHBsAg? The only explanation I can find is:
Undetectable hbvdna means very little or no re-infection - refurbishment of the cccDNA pool, and natural liver cells turnover during which some cccDNA are lost.
So my question about diet is: can moderate wine drinking accelerate liver cells turnover? This is highly speculative as drinking is definitely not recommended for hbvers.
Most of the 5 patients have relatively low qHBsAg at pre-suspension. So why are antivirals able to gradually bring down qHBsAg? The only explanation I can find is:
Undetectable hbvdna means very little or no re-infection - refurbishment of the cccDNA pool, and natural liver cells turnover during which some cccDNA are lost.
So my question about diet is: can moderate wine drinking accelerate liver cells turnover? This is highly speculative as drinking is definitely not recommended for hbvers.
yes data is at pre suspension, they also clarify the limit of no baseline hbsag but in 2000 it was not available and known as an important test.
they are probably all genotype D since these are patient from a university hospital in rome.they say seroconversion happened with normal alt, even for the patient with hbsag 2381 this also shows a complitely different immune response with no killing of infected hepatocytes but just repair of dna and purging of cccdna
I wonder whether diet may also play some roles?
i think this is only the effect of restoring t cells by antiviral
they are probably all genotype D since these are patient from a university hospital in rome.they say seroconversion happened with normal alt, even for the patient with hbsag 2381 this also shows a complitely different immune response with no killing of infected hepatocytes but just repair of dna and purging of cccdna
I wonder whether diet may also play some roles?
i think this is only the effect of restoring t cells by antiviral
Thanks Steff mate good read.
I would agree with Vet B on this far superior options are out there but just not available to us bunch peasants! oh sorry I was meant to say sufferers!
I would agree with Vet B on this far superior options are out there but just not available to us bunch peasants! oh sorry I was meant to say sufferers!
thanks for the info, but why my hbsag value was increasing whiles on lamivudine which prompted me to stop using it.
Thanks for the very interesting presentation!. It certainly supports the theory that lowering serum HbsAg will lead to restoration of the T-cell immunity, thereby leading to the clearance of the virus.
Pardon my Italian, I don't think there were any data of baseline qHBsAg. I think at pre-suspension, qHBsAg were:
Patient
1 70.7 iu/ml
2 164
3 2381
4. 34
5 6269.
Patient 5 did not seroconvert, his/her qHBsAg was too high. It was good that Patient 3, with qHBsAg at 2381, did seroconvert. Also, most have a small brief hbvdna flare, I wonder whether they were followed by a small ALT flare too?
Without knowing the pre-treatment qHBsAg, it is hard to determine the rate of lowering of qHBsAg whilst on Lam treatment.
I have a feeling that all of these patients are genotype D, they do seem to do better in s-seroconversion. I wonder whether diet may also play some roles?
Pardon my Italian, I don't think there were any data of baseline qHBsAg. I think at pre-suspension, qHBsAg were:
Patient
1 70.7 iu/ml
2 164
3 2381
4. 34
5 6269.
Patient 5 did not seroconvert, his/her qHBsAg was too high. It was good that Patient 3, with qHBsAg at 2381, did seroconvert. Also, most have a small brief hbvdna flare, I wonder whether they were followed by a small ALT flare too?
Without knowing the pre-treatment qHBsAg, it is hard to determine the rate of lowering of qHBsAg whilst on Lam treatment.
I have a feeling that all of these patients are genotype D, they do seem to do better in s-seroconversion. I wonder whether diet may also play some roles?
That is all good. But Replicor can lower surface antigen in 2 weeks. And interferon can do svr that will hold in 3 months.
Do they also report toxicity findings tenofovir does over 17 years as well as kidney function. ?
Interferon can cure people in 6-12months alone at 20-50% rate. New medications like Rep9 can do it even faster.
Yet we talk about nucs here all the time. As if HBV is that complicated as HIV.
Do they also report toxicity findings tenofovir does over 17 years as well as kidney function. ?
Interferon can cure people in 6-12months alone at 20-50% rate. New medications like Rep9 can do it even faster.
Yet we talk about nucs here all the time. As if HBV is that complicated as HIV.
One thing i was not precise
patient 1 hbsag und
patient 2 hbsag 20
patient 3 hbsag 70
patient 4 hbsag und
patient 5 hbsag 5000
patient 3 had hbsag 2381 when he stopped lam
patient 5 had hbsag 6269 when he stopped lam
i thin hbsag 20-70 will slowly clear on its own with no need of peg, but patient 5 will go nowhere without peg add on because no t cell rescue happened for him
patient 1 hbsag und
patient 2 hbsag 20
patient 3 hbsag 70
patient 4 hbsag und
patient 5 hbsag 5000
patient 3 had hbsag 2381 when he stopped lam
patient 5 had hbsag 6269 when he stopped lam
i thin hbsag 20-70 will slowly clear on its own with no need of peg, but patient 5 will go nowhere without peg add on because no t cell rescue happened for him
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