my HBsag DNA quantitative results - kindly advice

[sun2011]

Hi

I am having chronic Hepatitis -B for more than 5 years now since identified
Kindly suggest on below results

Results of test done on Feb - 2011
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SGOT - 19
SGPT - 21
HBV DNA Quantification COBAS TaqMan -     110   IU/ml
Log Value           -          2.04


Results of test done on Apr-2012
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SGOT - 43
SGPT - 86
HBV DNA Quantification COBAS TaqMan -     40 IU/ml
Log Value           -          1.60

If the HBV DNA quantitative is less compared to previous results ,does it indicate any progress or chances in clearance
I have'nt taken any medication for past 1 year

Thanks & regards

[stef2011]

to dfine hbv status correctly:

fibroscan, only tool to monitor liver damage or repair accurately
hbsag, reflects infected cells and balance hbv/immune system
hbvdna, virus replication but hbvdna undetactable doesn t mean there is no virus replication.more a measure of antivirla efficacy
ast/alt hepatocytes lysis in the moment you take the test

hbeag, very good if positive, when positive virus has nt yet mutated and escaped a step of our immune respose to hbv so therapy has more chances to clear hbv

there are no hbv cures and monotherapies hae very poor clearance but sequential treatment tenofovir and then peginterferon add on has show for the first time good rates of hbv clearance.the goal of all therapies is hbsag negative and not just hbvdna und

[stef2011]

all meaningless without hbsag in iu/ml, hbeag and fibroscan

hbvdna alone has very little meaning out of therapy because hbv life cycle and replication is not hbvdna and also the values of ast/alt and hbvdna have little meaning as regards liver damage

anyway you may expect low liver damage with such low hbvdna but only fibroscan can confirm

with a low hbsag less than 1500iu/ml you have good chances to clear hbv with interferon+tenofovir especially if hbeag pos