Aa
hbig
Hi
Maybe my question is stupid but I just to understand this.as I know baby from woman hbv+receive hbig (injection contain hbsab in big quantity to help him to eliminate hbsag bnecause of fragile and weak immune sys if contact with hbsag of mother.then injection of vaccin ro boost immune system).
Why not we hbvers these injections to lower our hbsag and sure when hbsag be in small quantity maybe our immune syst react!!.
Could someone explain more.please
Maybe my question is stupid but I just to understand this.as I know baby from woman hbv+receive hbig (injection contain hbsab in big quantity to help him to eliminate hbsag bnecause of fragile and weak immune sys if contact with hbsag of mother.then injection of vaccin ro boost immune system).
Why not we hbvers these injections to lower our hbsag and sure when hbsag be in small quantity maybe our immune syst react!!.
Could someone explain more.please
when you are down to like 1 iu/ml, you could temporarily remove the hbsag, for a day or two using thousands of dollars worth of hbig. then it will bounce back to the same level.
Several hundred ius/ml would require hugh, unaffordable amounts of hbig for neutralization. And it would still bounce back in two days. Furthermore there would be the danger of huge amounts of kidney damaging immune complexes.
All this has been tried in the past.
one trial in the netherlands with hbig. hbsag back in days to status quo.
one trial in england and germany by boehringer ingelheim in which a humanized anti hbsag monoclonal by the name of OSTAVIR. hss been used.
Stopped due to kidney damage.
And the biggest trial in the usa by an israeli company, XTL, that developed a dual human monoclonal antibody, later sold to CUBISTS , a us company under the brand name HEPEX B.
they were able to suppress hbdsg up to like 300 iu with huge amounts of this monoclonal, that seemed to not affect the kidneys as immuncomplex.
the hbsag returned after a few days to full strength. In the patients with the lowest starting amounts they were able to keep it low for two weeks with ongoing infusions.
Nothing useful was achieved in this trial. Cubist bought the rights from xtl , because they wanted to use it for post transplant prophylaxis. They were unable to meet the fdas demands for a phase 3 trial snd dropped further development of HEPEX B.
Several hundred ius/ml would require hugh, unaffordable amounts of hbig for neutralization. And it would still bounce back in two days. Furthermore there would be the danger of huge amounts of kidney damaging immune complexes.
All this has been tried in the past.
one trial in the netherlands with hbig. hbsag back in days to status quo.
one trial in england and germany by boehringer ingelheim in which a humanized anti hbsag monoclonal by the name of OSTAVIR. hss been used.
Stopped due to kidney damage.
And the biggest trial in the usa by an israeli company, XTL, that developed a dual human monoclonal antibody, later sold to CUBISTS , a us company under the brand name HEPEX B.
they were able to suppress hbdsg up to like 300 iu with huge amounts of this monoclonal, that seemed to not affect the kidneys as immuncomplex.
the hbsag returned after a few days to full strength. In the patients with the lowest starting amounts they were able to keep it low for two weeks with ongoing infusions.
Nothing useful was achieved in this trial. Cubist bought the rights from xtl , because they wanted to use it for post transplant prophylaxis. They were unable to meet the fdas demands for a phase 3 trial snd dropped further development of HEPEX B.
What about those who has small quantity o hbsag?and why dont use a big quantity of hbig corresponding to quantity of hbsag of a patient?
the amount of hbsag circulating in an infected person is dramatically higher than any level that hbig could neutralize and reduce.
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