hbv Classification, biology, life cycle, in vitro and in vivo model

[stef2011]

http://www.hepatologytextbook.com/hep_chapt05.pdf

Furthermore, it appears that most studies have been
driven by commercial interest rather than addressing public scientific interest.........i guess anybody noticed that all studies are commercial intrest only

very good article

[stef2011]

have you found something about the replication cycle of hbv with hbvdna undetactable, pgrna and cccdna replication cycle

i have seen there are new studies presented at easl conference but those posters/presentations are not accessable for free only pay per view docs, i guess we should see something free about it around the net or sci journals

[stef2011]

i can answer those questions by old HR posts:

1. HbSAb only appears in sufficient quantity when the infection is resolved

hbsab is always present but the number of hbsag antigens (probably carring nagalase) neutralizes hbsab.the solution of hbv infection is simply blocking hbsag like replicor drug

HR gave a good explanation on old posts, maybe serching under HR or hepatitisresearcher those posts can be found

2. Why appearance of HbEAb signals non-replicative  phase.

not important nowadays, this is an old view and hbeag is not usefull anymore because hbsag quant is much better to follow evolution of infection

hbeag is another antigen of hbv which suppresses immune system like hbsag.
when the immune system makes hbeab antibodies on cronic carriers it is just a mutation of the virus which stops making hbeag to replicate freely from immune pressure

those getting hbvdna undetactable when seroconverting to hbeab have usually wild type virus or strong immune system suppressing both wildtype or the mutants

it is easier to follow hbsag quantity, when it is low you get both hbvdna undetactable and hbeag negative on wildtype or mutated hbv.a low hbsag quant reflects exactly immune system pressure on virus

[StephenCastlecrag]

Very technical. It offers no explanation why
1. HbSAb only appears in sufficient quantity when the infection is resolved
2. Why appearance of HbEAb signals non-replicative  phase.