hepatitis B ,platelets down level, polyurie

[hingmary]

Hello

I've got hepatitis for year ago. I've checked blood regularly either HBV/DNA(10300 copies) HBeAg ( -) HBeAb ( + ).
or others blood tests.After i took lamivudine  100 mg /day ,2 months later HBV/DNA negative level ,after 16 months HBsAg (- ) HBsAb ( - ) HBeAg  ( -) HBeAb ( + ).,prothrombine time 100 INR  1,0. gama GT 19 ui/l ,sgot 36 u.i/l SGPT ,calcemia 9,7mg/dl55 u.i/l bilirubine 13Mmol/l GLYCEMIA 74mg/dl creatinine 1,2 mg/dl ,blood cells count are normal range ,platelets  first blood test 116.000 mmcube. after 1 month seconde blood test 147.000 mm cube  ( absent agregation platelet on frottis colore) ,i often got purpura (ecchymose on the skin )  neither gingivitis nor  epistaxis ,insomnia , urine transparent ,abondant ,frequently /day (not diabete sign ) creatinine 1,2mg/dl, albuminemia 4,8g/dl
could you please answer my questions?
_ Cause of platelets down subsequently Is   it make me a disease?
_ polyurie :  urine transparent ,abondant, frequent .cause and treatment ?
_ purpura on the skin  ?
_  my country the doctors specialized are not available to consult
sincerely yours

[Thomas D Schiano, MD]

the platelets could be decreased because of a lot of fibrosis in the liver.  if the HBV DNA is undetectable then the purpura cannot be related to the HBv but could be due to the low platelets

[hingmary]

hello
thanks for your reply, I am 59 year old, male,  i would like to know that if my blood test ,HBV/ DNA ,still negative level, HBeAb ( + ) HBsAg ( - )  take regularly lamivudine 100 mg /day. Is the fibrosis can be stopped, or virus hepatitis B to  decreased to kill the liver cells ? and what's about the polyurie : urine clear, abondant, frequent ? what shall i do ? is it the cause of virus hepatitis B ? or not .
every day ,i have 3 meals by rule of dietary food for hepatitis patient . A lot of vegetables and fruits ,not red meat,  replaced by soy bean , 1 liter /day.
Thanks

[stevenNYer]

you wrote:

after 16 months HBsAg (- ) HBsAb ( - ) HBeAg  ( -) HBeAb ( + )

Are you still HBV DNA negative?

If you were HBeAg (-) and HBeAb (+) before treatment, and your doctor started you on treatment, usually treatment is long term.  And if long term, Lamuvidine monotherapy is not a good choice since there is risk for resistance.  

[hingmary]

hello
thanks for your reply,i've said to you that HBsAg ( positive) ,HBsAb (negative ) HBeAg (negative) ,HBeAb ( positive ) ,HBV/DNA ( 10300 u.i /copies /ml that is before treatment . After examination of echography of abdomen showed that the liver have had scar tissue all over the surface of the liver ,and fibroscan machine result that F 3.
After treatment ,2 months ,it's appeared HBV/DNA ( negative)  ,after 16 months HBsAg ( negative) ,HBsAb ( negative) .I've checked regularly HBV/DNA still negative . I would like to know that :
                     1 - when i can stop lamivudine 100 mg, if it's still neative ( DNA/HBV ), HBsAg (negative).
                      2- Is my liver to progress cirrhosis levelto progress up level F4, or not ( because the platelets still down level ' normal ( 113 to 155 000 mm cube.) and prothrombine time 100% I N R, anothers tests are acceptable  (normal range)
                       3- How about the urine clear, abondant,( after i drink water a small quantity) frequent,no sign  diabete ,it is related to hepatitis or not ?

Thanks

[stevenNYer]

I think you should test your HBsAg and HBsAb again.  Something doesn't feel right.  If you are the lucky 1-3% that clear HBV with antiviral treatment, you should eb HBsAg -  and HBsAb +.

If your labs are correct, you may want to give it more time to see if you turn HBsAb +.  There is the concern of "going back" if you stop treatment and you immune system is acutally not doing too much to hole the virus.

I'm don't know enough on cirrhosis to comment on it.

As for urine, it's more related to kidneys.  I don't think it the hepatitis.