nizoral tablets might damage hbsag, in vitro reduction 72%

[stef2011]

http://onlinelibrary.wiley.com/doi/10.1002/jmv.1890160308/abstract

ketoconazole makes damage to hbsag lipids probably the same way as statins do.if you use these pills or statins you must check liver function monthly because although rare both statins and especially ketoconazole might make liver damage and in that case it is better to stop these pills

i also suggest to use antioxidants like fibroguard, heptech, heptoshield, liposomal glutathione and liposomal vitamin c, these antioxidants will probably block any liver damage.i am using this products continuatively to reverse all cirrhosis

How does it work?
Nizoral tablets contain the active ingredient ketoconazole, which is a type of medicine called an antifungal. It is used to treat infections with fungi and yeasts.
Ketoconazole kills fungi and yeasts by interfering with their cell membranes. It works by stopping the fungi from producing a substance called ergosterol, which is an essential component of fungal cell membranes. The disruption in production of ergosterol disrupts the fungal cell membrane, causing holes to appear in it.
The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. As ketoconazole causes holes to appear in the cell membranes, essential constituents of the fungal cells can leak out. This kills the fungi and treats the infection.
When taken by mouth ketoconazole may very rarely cause serious side effects on the liver. As a result, Nizoral tablets are reserved for treating fungal infections that can't be treated with other antifungals.

[stef2011]

Ketoconazole inhibited cholesterol synthesis (greater than 90% suppression in 1 hr) rapidly by blocking the conversion of methyl sterols to cholesterol.

this is really a lot.....i wonder if this is more potent than statins

http://jpet.aspetjournals.org/content/238/3/905.short

here is a full article, i will read it fully later
chol kinetics ketoconazole
http://www.jlr.org/content/34/1/59.full.pdf+html

[stef2011]

the reason of activity on hbsag

Abstract

Studies have demonstrated that ketoconazole and related imidazoles block gonadal and adrenal steroidogenesis in humans by inhibiting several cytochrome P-450-dependent enzymes. Moreover, recent evidence suggests that cholesterol production in humans is also affected by ketoconazole. In the present experiments cultured normal human fibroblasts have been used to explore the effects of ketoconazole on cholesterol synthesis. Ketoconazole inhibited cholesterol synthesis (greater than 90% suppression in 1 hr) rapidly by blocking the conversion of methyl sterols to cholesterol. Dihydrolanosterol was the major methyl sterol which accumulated with ketoconazole. At high concentrations of ketoconazole, the conversion of squalene to methyl sterols was also inhibited. The inhibition of cholesterol synthesis was dose-dependent with an IC50 approximately 2.8 X 10(-8) M. In parallel to the inhibition of cholesterol synthesis, there was a reciprocal increase in methyl sterol production. The related imidazole antimycotic, clotrimazole, had similar effects, whereas the imidazole anesthetic, etomidate, had little effect on cholesterol synthesis. Confluent cells exposed to ketoconazole had a 90% fall in the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase that declined with a T1/2 approximately 3.7 hr. In conclusion, ketoconazole has multiple effects on cholesterol synthesis, directly inhibiting late steps by blocking the conversion of methyl sterols to cholesterol and indirectly suppressing total sterol synthesis via feedback inhibition by sterol intermediates of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity.

[miracle852]

Stef, I thought this is talking about fungi and not viral infection. Does it work the same way? Meanwhile, just wish to know. Are you a medical doctor?

[stef2011]

this is another clear example of how drug makers avoid ANY study about hbsag reduction.......it is better to check research ourselves since most of these drugs are already approved from a long time and very cheap generics.
the evidence is that anything that destroys or lowers lipids damages hbsag virus coat