Read it in full nothing new leaping out at me just mainly suppression stuff... I wonder once Replicor is on the market 3 maybe 4years time then hey this stuff won't seem that relevant but thank you for sharing Steff2011 Oh by the way the World Hep fund posted this on face book :) https://www.************/photo.php?fbid=189327787944190&set=a.116189521924684.1073741826.114866245390345&type=1&theater
with replicor, myrcludex you just fasten the process but results are the same, going more than 90% response on hbsag is not that probable/meaningful
you wont see anything new on the market before 5-10 years so i dont think it is uselful to talk about these drugs anymore until they show results on patients or they really get to market, since the cure is available to all and it is slow it is best to cure hbv now by the sequential combo available
the years of hbvdna undetectable of course and very probable IP10 serum levels which can guide on the best time for pegintf add on, to see immediately those that can respond after 3 years and those needing 5-6 years
i hope dr Ouzan measured ip10 levels too or has frozen blood sample to continue research, i am sure ip 10 can help on this
Steff2011 they have results on patients already not just animal testing please see link http://www.replicor.com/debut_anglais2.htm
The world Hepatitis Fund are saying on face book potentially 3years not 5years like you said. Its very close :) .... I Think judging by the data so far on Replicor the clearance rate 8out of 9 patients...
As long as there is focus on it and talk about it the less its forgotten the better in my view...
Could you explain a bit when you said "with replicor, myrcludex you just fasten the process but results are the same, going more than 90% response on hbsag is not that probable/meaningful"?
What do you mean more than 90% response on hbsag is not that probable or meaningful? Are you suggesting that 60% cure rate with Rep 9AC is the best we could expect, same level as current Nuc+Peg could achieve? I thought with Rep 9AC or Myrcludex we can reach 100% cure rate. thank you very much.
i have noticed some peg add on trials are been designed with nucs monotherapy.
do you think suppressing intrahepatic hbvdna too much can also lower immune response due to less virions?what about a staggered regimen with the second nuc?
in this study, although very small, nuc mono had much more response than combo nucs (if we assume hbsag level is not important once cd8 response is recovered)
This study has too low numbers for firm conclusions. What can be seen again is that the ongoing internal suppression, exemplified by low hbsag concentrations before the peg ifn start, is critical to achieve hbsag negativity.
The low virion production under nucs leads to a reduction of class II response and therefore less inflammation and pro fibrotic stimulation, hence the clinical improvement under nucs. At the same time, the constant overstimulation and exhaustion of cd8 T cells is reduced, leading to at least a partial recovery of HBV specific cd8 clones, this causes the improvement after waiting undetectible under nucs for years in the response to peg ifn.
The difference in antiviral efficacy using combos is small, the main virtue of combos is crossprotection from resistance. Nevertheless, there could be a difference in residual stimulatory power, as you suspect. The data available are however way too limited for a firm conclusion.
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