Aa
regressison of cirrhosis 48weeks etv+alinia
a wonderful update after 48weeks of my treatment with baraclude 0.5mg (entecavir) plus alinia (nitazoxanide) 1.5g daily
i also changed diet with antioxidants known to reduce fibrosis in anima studies:bluberries, melatonin,omega3,green tea
cirrhosis regressed (not reversed), fibroscan 9kpa about f2 to f3 borderline, i started with a baseline value of 15.9 november 2009, 16.3 in march 2010, 13.9 in july 2010.
(cutoff values for F0 4.0kpa, F1 about 6.5, F2 about 7.1, F3 9.1 and F4 12.5)
this confirms baraclude as the most fast antiviral in cirrhosis regression while viread is better on less fibrosis stages
to talk about cirrhosis reversal (which takes years of hbvdna und)
in december we will check deeply by ultrasound to see if nodules have been absorbed or are disapearing and if structure of the liver is slowly getting back to normal, it is also important to reach F0 at 4-5kpa, if all this happens we might talk about cirrhosis reversal and not only fibrosis regression, but anyway this is not important because even if the structure of the liver is not like before cirrhosis the liver can adapt and work perfectly if fibrosis is zero
i also changed diet with antioxidants known to reduce fibrosis in anima studies:bluberries, melatonin,omega3,green tea
cirrhosis regressed (not reversed), fibroscan 9kpa about f2 to f3 borderline, i started with a baseline value of 15.9 november 2009, 16.3 in march 2010, 13.9 in july 2010.
(cutoff values for F0 4.0kpa, F1 about 6.5, F2 about 7.1, F3 9.1 and F4 12.5)
this confirms baraclude as the most fast antiviral in cirrhosis regression while viread is better on less fibrosis stages
to talk about cirrhosis reversal (which takes years of hbvdna und)
in december we will check deeply by ultrasound to see if nodules have been absorbed or are disapearing and if structure of the liver is slowly getting back to normal, it is also important to reach F0 at 4-5kpa, if all this happens we might talk about cirrhosis reversal and not only fibrosis regression, but anyway this is not important because even if the structure of the liver is not like before cirrhosis the liver can adapt and work perfectly if fibrosis is zero
i forgot to tell you to add nac (acetylcisteine) too from start, this is a potent antioxidant/immune booster which helps liver and kidneys work better, the dose in heptech protocol is 2400mg daily and i am using this dose from 15 sept
if you see cirrhosis from ultrasound it is well advanced, you should have monitor by fibroscan and not blood tests, we now know all blood tests are useless in terms of fibrosis and liver damage
you must get immediately hbvdna<10iu/ml or und, alt<30, hbe negative, so that the virus can make no damage to you
follow through the posts the same antioxidants i used not only bluberries, when hbvdna is und, hbe negative and alt<30 you can add all the list posted here:
http://www.medhelp.org/posts/Hepatitis-C/Research-supported-antifibrotics---do-they-exist/show/346752
it is better to use all of them when antiviral has suppressed all virus to avoid interference
you can also get all these supplements from hepatitistechnologies, if you google it you will find it
entecavir is the best choice but it is necessary to make a resistance test before you start it because it doesn t work if LAM mutants are present, these mutants can be present naturally or after therapy with this drug
it is also very important to check liver by fibroscan every 3-6 months to see improvement in fibrosis
i also used alinia (nitazoxanide), at the moment it is better not to use it because it is off label and we don t have any proff it can also act as antifibrotic, but if you see no improvement by fibroscan after 6 months you should try to add alinia too.it has a stong effect on apoptosis of cells so theoretically it might have a little effect on fibrosis too but there is no proof so do not use it at first
also follow my posts about alinia and if you see i get hbsag negative or very very low you might add it too because a reduction of hbsag in vitro has shown to reverse HCC growth
i wish you can reverse cirrhosis as soon as possible, do post your fibroscan results and check for liver cancer every 6 months by ultrasound because you have the highest risk of liver cancer until fibroscan is more than 10kpa, any value of fibrosis lower than 10kpa is safer
you must get immediately hbvdna<10iu/ml or und, alt<30, hbe negative, so that the virus can make no damage to you
follow through the posts the same antioxidants i used not only bluberries, when hbvdna is und, hbe negative and alt<30 you can add all the list posted here:
http://www.medhelp.org/posts/Hepatitis-C/Research-supported-antifibrotics---do-they-exist/show/346752
it is better to use all of them when antiviral has suppressed all virus to avoid interference
you can also get all these supplements from hepatitistechnologies, if you google it you will find it
entecavir is the best choice but it is necessary to make a resistance test before you start it because it doesn t work if LAM mutants are present, these mutants can be present naturally or after therapy with this drug
it is also very important to check liver by fibroscan every 3-6 months to see improvement in fibrosis
i also used alinia (nitazoxanide), at the moment it is better not to use it because it is off label and we don t have any proff it can also act as antifibrotic, but if you see no improvement by fibroscan after 6 months you should try to add alinia too.it has a stong effect on apoptosis of cells so theoretically it might have a little effect on fibrosis too but there is no proof so do not use it at first
also follow my posts about alinia and if you see i get hbsag negative or very very low you might add it too because a reduction of hbsag in vitro has shown to reverse HCC growth
i wish you can reverse cirrhosis as soon as possible, do post your fibroscan results and check for liver cancer every 6 months by ultrasound because you have the highest risk of liver cancer until fibroscan is more than 10kpa, any value of fibrosis lower than 10kpa is safer
What makes the patient achieving above results is the medical therapy which suppresses the active of cccDNA. But if therapy halted cccDNA may be active again. The root is still there. It is the source of HBV. This kind of therapy is only a temporary cure.
hbv persists because it suppresses immune system mainly by hbsag, if you remove hbsag the underlaying antibody hbsab takes control of hbv and cccdna slowly decreases to und by our assays but it is not zero, it may persist all life.
do not rely on old studies because they use wrong words or are wrong, for many viruses and hbv family also, eradication doesn t exist they can only controlled to und by immune system but the template is hidden inside cells, herpes, papilloma virus, citomegalovirus and many others, they all have the residual template hidden but until immune system works you might say they are cured or und
This kind of therapy is only a temporary cure.
no if it is immune system to take control it is definitive.we have millions of viruses/bacteria inside us in a balance with immune system, if you like you can consider it hbv eradication because it makes no difference until you have an immune system.
as an example why aids patients get all kinf of viruses/bacteria/cancers once immune system is destroyed, the viruses were already inside the body and once immune system lose control they attack the body
at present there is no way to eradicate hbv cccdna, herpes virus, papilloma virus and many others, they stay hidden inside cells in a balance between immune system and virus.actually is a similar concept of health, health is a balance, perfect health doesn t exist
hbv persists because it suppresses immune system mainly by hbsag, if you remove hbsag the underlaying antibody hbsab takes control of hbv and cccdna slowly decreases to und by our assays but it is not zero, it may persist all life.
do not rely on old studies because they use wrong words or are wrong, for many viruses and hbv family also, eradication doesn t exist they can only controlled to und by immune system but the template is hidden inside cells, herpes, papilloma virus, citomegalovirus and many others, they all have the residual template hidden but until immune system works you might say they are cured or und
This kind of therapy is only a temporary cure.
no if it is immune system to take control it is definitive.we have millions of viruses/bacteria inside us in a balance with immune system, if you like you can consider it hbv eradication because it makes no difference until you have an immune system.
as an example why aids patients get all kinf of viruses/bacteria/cancers once immune system is destroyed, the viruses were already inside the body and once immune system lose control they attack the body
at present there is no way to eradicate hbv cccdna, herpes virus, papilloma virus and many others, they stay hidden inside cells in a balance between immune system and virus.actually is a similar concept of health, health is a balance, perfect health doesn t exist
greeting,
is u have mention about the blueberry,melatonion,omega3,
dear friend i am a patient from 2003 to hepatitis b upto 2009 i repeat every year the DNA test it was negative each year without any medication.but now in 2010 i tested positive for DNA i consult the doctor he advise me enticavir for 2 years.my liver ultasound show cirhosis impression.
my question is that can i used these three ingridients and also tell what HBeAg means.
thanks
is u have mention about the blueberry,melatonion,omega3,
dear friend i am a patient from 2003 to hepatitis b upto 2009 i repeat every year the DNA test it was negative each year without any medication.but now in 2010 i tested positive for DNA i consult the doctor he advise me enticavir for 2 years.my liver ultasound show cirhosis impression.
my question is that can i used these three ingridients and also tell what HBeAg means.
thanks
Sorry I still haven't got the point.
HBsAg, which indicates current Hepatitis B infection, is the surface antigen of the Hepatitis-B-Virus (HBV). An antigen is a molecule recognized by the immune system
A "negative" HBsAg test result means that the person is NOT infected with the hepatitis B virus.
HBsAb is the hepatitis B surface antibody. The antibody protects against Hepatitis-B-Virus (HBV) infection.
A "positive" HBsAb (or anti-HBs) test result indicates that the patient has recovered from hepatitis B infection. This result means that the patient is immune to hepatitis B infection.
What makes the patient achieving above results is the medical therapy which suppresses the active of cccDNA. But if therapy halted cccDNA may be active again. The root is still there. It is the source of HBV. This kind of therapy is only a temporary cure.
HBsAg, which indicates current Hepatitis B infection, is the surface antigen of the Hepatitis-B-Virus (HBV). An antigen is a molecule recognized by the immune system
A "negative" HBsAg test result means that the person is NOT infected with the hepatitis B virus.
HBsAb is the hepatitis B surface antibody. The antibody protects against Hepatitis-B-Virus (HBV) infection.
A "positive" HBsAb (or anti-HBs) test result indicates that the patient has recovered from hepatitis B infection. This result means that the patient is immune to hepatitis B infection.
What makes the patient achieving above results is the medical therapy which suppresses the active of cccDNA. But if therapy halted cccDNA may be active again. The root is still there. It is the source of HBV. This kind of therapy is only a temporary cure.
once hbsag is negative your immune system will work again like for all other people who cleared hbv, hbsag is the main immune system suppressor
the ways to lower hbsag already available are:
interferons, boosting interferon effect by nitazoxanide and entecavir or tenofovir.the best way is start with ntz follwed by entecavir or tenofovir after 4-12 weeks because also hbvdna suppress immune system and some interferon non responders become responders after hbvdna is und by entecavir or tenofovir, so the combo of these drugs will make hbsag lowering (results from previous trials interferon+adefovir better results than all other therapies but still too weak, telbivudine+interferon sides)
very near future:
interferon lambda which is by far better than normal interferons with no sides will be the way of the future since combined with etv and tnf will have no issues
who knows when:
rep9ac from replicor
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