Aa
A
A
Close
Avatar_universal
simvastatin
curious if stef2011 or studyforhope or StephenCastlecrag know whether simvastatin by itself can reduce viral load?  I've read about the effects in conjunction with NUCS but I'm curious if sim is effective alone.
Cancel
3 Answers
Page 1 of 1
Avatar_universal
was that the invitro study or a human study?unfortunately no human study started that i know of although they were on schedule since 2008-2009 so this makes me suspicious......

i tried it for hbsag but no effect on me and otan tried it in combo with pegintf and she had a superfast result hbsag und in less than 16weeks and then seroconverted to hbsab in the following months

those on peg may try this combo to confirm if it was sim or just a coincidence
Comment
Cancel
Avatar_universal
Comment
Comment
Submit Comment
Avatar_universal
I have no idea, that is, I don't know.

As for stef2011's comment, I think there is a distinction between reducing HBsAg and reducing viral load.
Comment
Cancel
Avatar_universal
Comment
Comment
Submit Comment
Avatar_universal
There was an in vitro study on ezetimibe inhibiting HBV DNA production. The ed50 was fairly low and in a similar range as lamuvidine. So it looked very interesting. But in an in vitro study you have a constant exposure to the drug, which is impossible to achieve in vivo. And the cells used are not the same as regular hepatocytes in human liver, with many differences in gene expression and cellular physiology.
Nitazoxanide, brand name alinia, had also excellent ed50 results in an in vitro inhibition study, just as good as lamuvidine, so this sounded fascinating for a possible combination towards true synergism, to finally suppress virion production to a level so low that the silent daily reinfection will be reduced, allowing a slow net clearance of infected cells with a resulting drop in surface antigen. But again, the in vivo pharmacokinetics does not seem to match the in vitro data, as stefanos personal trial has sadly demonstrated.
Comment
Cancel
Avatar_universal
Comment
Comment
Submit Comment
Your Answer
Avatar_universal
Answer
Know how to answer? Tap here to leave your answer...
Answer
simvastatin
Submit Answer
A
A
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Hepatitis B Community Resources
RSS Expert Activity
233488_tn?1310696703
Blank
Marathon Running Done Over Many Yea...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
233488_tn?1310696703
Blank
New Article on Multifocal IOL vs &q...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
748543_tn?1443740527
Blank
TMJ/TMJ The Connection Between Teet...
01/15 by Hamidreza Nassery , DMD, FICOI, FAGD, FICCMOBlank
Top Hepatitis Answerers
Avatar_m_tn
Blank
StephenCastlecrag
Australia
Avatar_m_tn
Blank
stef2011
Italy
Avatar_m_tn
Blank
Jatashankar
India
Avatar_m_tn
Blank
sorte
Poland
Avatar_m_tn
Blank
luckyman316
Avatar_m_tn
Blank
Aduiski
Other