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which drug to use??
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which drug to use??

Dear all, I am a chronic Hepatitis B patient who have drug resistence to Lamivudine and Entecavir, and my Kidney is not good(Creatinine=3.7). Doctor said my only next choice of drug is to use Pegylated Interferon(Pegasys), so my questions are: 1. any other drugs that is suitable for me except Pegylated Interferon?
        2. Are side effects of Pegylated Interferon quite serious and hard to handle if I have to use it?

Many thanks for your advice and sharing!

Mike.
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Avatar_m_tn

in the supplements i forgot
liposomal glutathione, which lowers intracellular cholesterol so the virus has less material to build antigens and virions

it is also good to menthion that at berlin conference they found an inverse relationship between hdl and hbvdna, so increasing hdl is also good, there are only 2 substances that increase hdl and are vitamins:
PANTETHINE, precursor of vitamin b5, no sides at any dose, 1500-2000mg daily would be good, the best is split doses at meals
niacin, vitamin too, it increases hdl at high dose and have sides at doses higher than 1000mg daily so i'd try pantethine only first or combo low dose niacin like 50mg or less taken at meals for a total of about 200mg daily

hdl is always good, centenarios have all been found to have very high hdl, hdl>60 (in US-uk-canada they use different units sometimes).centenarios are concentrated in my region and in a japanese island, they all have in common strong immune system , no diseases, high hdl, no stress, food produced and consumed directly in their home or from their own village
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Avatar_m_tn
I'm chronic hep b also... I think stef2011 will surely give you an advise... I haven't take any medications right now because of financial problems... I'm just praying i could be fine..
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Avatar_m_tn

since you have very little options left i'd go for gcmaf before trying interferon, we dont know yet if it works on hbv but theorically it should work since it eradicated hiv and cancers

i will be alble to tell you if 99% it works as on hiv when i receive my nagalase test.nagalase is an enzym which suppress immune system, if it is high your immune system is suppressed and there is no response to hbv like it happens in hiv and cancer

i'd suggest to buy it from gcmaf.eu as long as it is available since they make it available when they make trials, availability is updated monthly.take 24 shots minimum
if you are not in europe there might be custom problems so discuss this with them, the best option would be dry ice shipment but i dont know if it gets easily thru customs this way, or go pick it up directly in UK or netherlands
there is also a study made by prof ruggiero presented at int'l nephrology congress on gcmaf active to cure kideny  disease
http://www.marcoruggiero.org/pdf/vancouver.pdf
GcMAF at the World Congress of Nephrology 2011

this is my best suggestion
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Avatar_m_tn

as to other options of interferon, it can also severely damage kidneys although it may also make no damage but as you know interferon monotherapy has a very low result on hbv, i'd try interferon+alinia monitoring closely kidneys but do try gcmaf first because even if it doesnt work on hbv it might help your kidneys

another way to help your kidneys is:
http://www.hepatitistechnologies.com/

fibroguard can help kidneys too but i dont know the degree of your damage, if there is some function you will lower creatinine

another thing you must absolutely start as soon as possible is coq10, if possible take the solgar nano type or if you want to go for the cheap go to puritans's pride, the dose is about 500-1000mg a day for the normal coq10 or 200-300mg for the solgar nano, try the 500mg first and see what is does to creatinine
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Avatar_m_tn

i know all this because i also cannot tollerate tenofovir, my creatinine is normal range but when i tried tenofovir it jumped to 1.2 in one week

i take entecavir+alinia now and keep creatinine 1.01-1.1 by coq10, heptech product made it 0.87 in one month

i will be trying gcmaf in a couple of weeks in addition to entecavir and alinia

if you have cirrhosis do not stop antivirals even if you have resistance they will help to make less alt flares when gcmf activates your immune system but if your liver has no severe damage stop slowly all antivirals at 4-8 weeks of gcmaf (fast responders got hivrna und by 2-4 weeks) but take coq10 even during gcmaf

if you get rid of hbv keep using both coq10 and heptech fibroguard to recover from kidneys disease and follow nepho int'l congress 2011 to see how gcmaf can keep helping reverse your kidneys function
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Avatar_m_tn

there is also an experimental version of tenofovir with no kidneys tox but they won t make it available until tenofovir expires patent, 2015-2017, so it is useless to talk about it, no way to get it
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Avatar_f_tn
Dear stef2011,

Thanks for your quick reply! There is a lot of info. in your reply. I will need some time to digest it. I wish your nagalase test is good. Two short questions for the time being:

1. do you have chronic hepatitis B?
2. what is alinia for? what is coq10 for?

By the way, I have also just wrote an email to GcMAF.com to inquire them about using GcMaf.

Really appreciate your reply. Will request the pleasure to ask you more questions once I have, OK?

Best regards!
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Avatar_m_tn
I wish your nagalase test is good.

well no, it must be abnormal so we are 1005 sure than hbv and hiv work the same way and gcmaf works as fast as 10 weeks to eradicate hbv too

1. do you have chronic hepatitis B?
of course and it reached cirrhosis

2. what is alinia for?
decrease hbsag and clear hbv
what is coq10 for?
make kidneys work better if there is some function left

that's ok no problem.what s your hbvdna now?the lower hbvdna when you start gcmaf the lower alt flare will be.
but hbvdna undetactable might be bad too because immune response after gcmaf might be weaker since there is less virus.i think that 100-1000iu/ml hbvdna is the best
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Avatar_f_tn
thanks!

1-which drug maker makes alinia and coq10?
2-my HBV-DNA is 10 to the power of 9(=1,000,000,000), quite high. GPT/ALT is 122 a week ago. Have done some more test yesterday. Will know the result next Wednesday when seeing doctor then.
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Avatar_m_tn
1-which drug maker makes alinia and coq10?

alinia brand is made by romark US, generics nizonide500 lupin india, nitarid cipla india, there are many others in central and south america too but dont remember all names

coq10, is a vitamin, many many brands, you can get from puritan's pride very cheap or get the most absorbable by nano liposomal technology coq10 nano from solgar.i have tried both and the nano version kept creatinine a little lower.
puritans cretinine 1.1
solgar nano creatinine 1.05 or less
my baseline creatinine before therapy was 0.95
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Avatar_m_tn
2-my HBV-DNA is 10 to the power of 9(=1,000,000,000), quite high. GPT/ALT is 122 a week ago. Have done some more test yesterday. Will know the result next Wednesday when seeing doctor then.

what about your liver?do you have biopsy or fibroscan?which such high hbvdna it might be possible to have an acute hbv when gcmaf activates immune system.
do you have a test of the resistance mutants you have?so maybe telbivudine or FTC plus alinia can lower hbvdna just for the time of making gcmaf, both antivirals shares some resistance mutants with lamivudine but knowing the mutants might help just a try

i wouldn t mess gcmaf with interferon and tenofovir might be like poison with such high creatinine.do you also have gfr or creatinine clearance results?
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Avatar_m_tn

theorically you can start alinia right away sine it is active on all mutants and try to lower cholesterol by liposomal glutathione (livonlabs) but these can only help with an antiviral.

i have seen some reports about a new drug on development in asia (china or korea), it is active on lamivudine mutants, it may help if the producers can give it to you.the kidneys tox was none on the trials.unfortunately i dont remember the name but it was something like N2378...
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Avatar_m_tn

the name of the drug is LB80380, it is active on lamivudine resistance mutations (lam makes some like 5-10 mutants) they dont say activity on etv mutants if you make the test and fid you only have lam mutants this drug+alinia might be the answer to lower hbvdna and gcmaf to finally eradicate infection in case gcmaf really activates the immune system to clear viral infections and cancers
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Avatar_f_tn
what about your liver?do you have biopsy or fibroscan?
=> Doctor said that I have light cirrhosis by the examination of ultrasonography . I have not      
      done biopsy or fibroscan yet.
which such high hbvdna it might be possible to have an acute hbv when gcmaf activates immune system.
=> I see.
do you have a test of the resistance mutants you have?so maybe telbivudine or FTC plus alinia can lower hbvdna just for the time of making gcmaf, both antivirals shares some resistance mutants with lamivudine but knowing the mutants might help just a try

i wouldn t mess gcmaf with interferon and tenofovir might be like poison with such high creatinine.do you also have gfr or creatinine clearance results?
=> I don't have gfr or CrCl yet. Will try to get it asap. what do you mean by" i wouldn t mess gcmaf with interferon and tenofovir"? I don't quite understand the English. can you explain  the sentence again?
=>I checked the web of Romark Lab for alinia which says alinia is now tested for Hepatitis C, not B. Can you comment again on that?
=> Can you give me a summary about what step by step actions(drugs and tests) I should do now since I lost track a bit after many discussions above. MANY MANY THANKS!
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Avatar_m_tn
what about your liver?do you have biopsy or fibroscan?

biopsy is useless to monitor fibrosis, it can be useful only in particular cases or to measure cccdna and total intrahepatic hbvdna.
i am monitored by the researchers who discovered hbsag quant, hbeag neg cronic (chronic) hbv mutants and making the studies on fibroscan statistical values so the best available in the world for now

i wouldn t mess gcmaf with interferon and tenofovir"

gcmaf+interferon, we cannot know if interferon interferes with a normal immune system response making unpredictable results, even severe damage.gcmaf is better alone or with antivirals

tenofovir would be good to use with gcmaf but it is not ok for your kidneys, tenofovir might destroy your kidneys function left

=>I checked the web of Romark Lab for alinia which says alinia is now tested for Hepatitis C, not B. Can you comment again on that?
dont check romark but check the studies posted on this community.romark has no money for trials and will have no pay back from alinia trials so they tried to make some trials on hcv but that's money wasted too because hcv has new antivirals too.believe what i say about alinia or check the studies links in the post in this community
use only the generics of alinia (nitazoxanide) the brand is too expensive.there are no sides to nitazoxanide but since you have kidneys failure you have to check creatinine and gfr for every drug you take and stop in case of damage.




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Avatar_m_tn
me a summary about what step by step actions(drugs and tests) I should do

- first of all find a good doctor, very expert, not the one who made all these resistance problems.the situation you have is only due to an ignorant doctor.a normal liver specialist would have started with entecaivr 1mg directly with less danager for mutations.
the only thing that might justify your doctor is if you had severe liver damage like cirrhosis and had to start therapy between 2000-2005 when only lamivudine was available and adefovir and tenofovir cannot be used because of your kidneys

- second test for mutations resistance to drugs

- look for an antiviral that works according to the results of resistance test, lower hbvdna and start gcmaf when hbvdna is about 1000iu/ml

- if no antiviral is found you can start nitazoxanide monotherapy for 4-12 weeks and then add interferon in combination, this way you might lower hbvdna and this will require 24-48weeks minimum

- when you have finished interferon+ntz you can try gcmaf.contact gcmaf.eu or bgli to be sure gcmaf will be available in the future otherwise it might be better to buy it when they are about to stop gcmaf supply since it lasts 6-12 months frozen -20°
only gcmaf from gcmaf.eu has been assayed to see potency, although i believe bgli.nl is probably similar potency my choice has been gcmaf.eu

during therapy withany of these drugs you have to monitor according to your doctor with all blood tests.
remember that creatinine is not good to monitor kidneys function because many on kidneys failure have normal creatinine (i think your doctor is ignorant for this too), all tests to monitor kidneys are very poor but gfr and creatinine clearance are the best we have now together with complete urine tests
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Avatar_m_tn

as to suplements to keep healthy liver and try to regress kidneys mulfunction:
coq10 and NAC to take immediately
fibroguard from hepatitistechnologies or if you can afford take the full pack of products (during interferon or gcmaf heptech products must not be used because they interfere with these drugs)
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Avatar_f_tn
thanks! and will do. I took lamivudine in 2001 when my kidney had no problem.

how do you think the following approach? which approach could be better for me?
I know I have to find out exact mutations resistance to drugs first per what you said above. My doctor said that I have drug resistence to Lam and Entecavir.  I will double check that later when I see my doctor.

1-Tenofivir
2-Tenofivir + Entecavir for dealing with multi-drug resistence per EASL 2011
3-Entecavir + GcMAF (starts when hbvdna is about 1000iu/ml )
4-Ntz(4-12 weeks)+Interferon(24-48 weeks; Pegasys OK?) if no antiviral drug is found suitable. then GcMAF thereafter.
5-Ntz+Entecavir
6. I am worried about the side effects of Interferon(Pegasys)?? how bad is it? how can I manage it well?

what is NAC and Fiberguard? By the way, how can you be so professional in HBV? Are you a doctor?
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Avatar_m_tn

in the supplements i forgot
liposomal glutathione, which lowers intracellular cholesterol so the virus has less material to build antigens and virions

it is also good to menthion that at berlin conference they found an inverse relationship between hdl and hbvdna, so increasing hdl is also good, there are only 2 substances that increase hdl and are vitamins:
PANTETHINE, precursor of vitamin b5, no sides at any dose, 1500-2000mg daily would be good, the best is split doses at meals
niacin, vitamin too, it increases hdl at high dose and have sides at doses higher than 1000mg daily so i'd try pantethine only first or combo low dose niacin like 50mg or less taken at meals for a total of about 200mg daily

hdl is always good, centenarios have all been found to have very high hdl, hdl>60 (in US-uk-canada they use different units sometimes).centenarios are concentrated in my region and in a japanese island, they all have in common strong immune system , no diseases, high hdl, no stress, food produced and consumed directly in their home or from their own village
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Avatar_m_tn
I am worried about the side effects of Interferon(Pegasys)?? how bad is it? how can I manage it well?

both my mother and sister dont want to hear about it, they both tried it and they thin real sh** about it (sorrry for the word but i saw what it does), some have no sides and some feel like dying.i am also trying gcmaf first because i dont wanna do it too
the only interferon with no sides is interferon lambda but it is not yet available, actually they shouldn t have done long trils for it and normal interferon should be put off market, too dangerous on sides.
this is just my thoght on it from my experience
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Avatar_m_tn
what is NAC and Fiberguard?
nac acetyl cisteine
fibroguard is the main product working on fibrosis reversal on heptech,these products made of vitamins and antioxidants have had human trials and have no sides

By the way, how can you be so professional in HBV? Are you a doctor?
probably much better than everage doctor but focused only on hbv.you just have to study to have more knowledge about your disease so you can see which drugs are ok and which are not since most doctors are too ignorant on this subject.i have found that only researchers have good knowledge on this.

researchers knew about lamivudine being a disaster even before 2000 this way i've saved myself and we have waited until safe antivirals were available.
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