Those numbers you are providing are the same reason my doctor did not see the need to Q80K test me .... and now I just finished my 3rd week. This treatment is so easy and my 2 week labs showed that all my levels were better then EVER before and that they were 100% normal range. In a week they will do labs again and also check the viral load. I am totally convinced this will be my LAST treatment!
You may be comparing apples and oranges when talking about QUEST 1&2 and Sovaldi/Olysio when talking about Q80K polymorphism. QUEST 1&2 were Olysio (simeprevier) and peg/riba.
COSMOS is a more appropriate comparison since it was sofosbuvir (Sovaldi) and simeprevir (Olysio). Below is what Ira Jacobsen said at last year's AASLD about the COSMOS results regarding Q80K:
"When looked at by HCV GT1 subtype, the results show that patients with the Q80K polymorphism did not fare as well. In cohort 1, 89% of patients with that polymorphism achieved an SVR12, compared with 100% of those with GT1a or 1b without Q80K. In cohort 2, 91% of those with the polymorphism achieved an SVR4, compared with 100% of the patients with GT1a or 1b who did not have Q80K. "
http://www.internalmedicinenews.com/index.php?id=2049&type=98&tx_ttnews[tt_news]=223225&cHash=da03e20e36
Granted, COSMOS didn't have a huge number of patients (80 in Cohort 1 and 87 in Cohort 2). Nevertheless, 89% and 91% SVR for those with the polymorphism are pretty darn good numbers. Good enough for me and my gastro, I'm 1a and planning to start Sovaldi/Olysio around the end of February (my gastro doesn't see the point of doing the polymorphism test).
smaug
Been taking Solvaldi 400mg once a day and Ribasphere 400mg twice a day for six days now to rid type 2 B hep C and very little side affects. The worst is no sleep or sleeplessness and a minor very minor headache in the back of my head. I never get headaches so I know it must be from the meds. The doctor said that the studies shown say this regime shows it actually only takes 4 days to kill most if not all the virus. But the regime still calls for 12 weeks. How are you handling these meds and what have you heard?
May I suggest you send a message to HectorSF? I think he can offer you some very good advice. His case, similar to yours, is nothing short of a miracle.
I wish you the very best. Hang in there.
Nan
Hello GrammyA need all the help right now have liver cancer ,two tumors on liver r cancerous and trying to get the solvaldi and olysio .had no success with inter fur on and Pegasus combo I don't know much about all of this and I want to live I'm on two transplant lists and I'm scared to death thanks for anything
Hepcat I have hep c geno type 1 end stage liver disease cirrhosis and liver cancer and battleing two tumors .on two transplant lists.doc wants to start me on this cocktail of solvaldi and olysio but insurance denied me saying a proper prior authorization is required before they will ok it .this is new for docs as well .my meld score is a 25. I want to live I work each day with the love of my life.she would die without me .do you have any suggestions I may use to help my docs .thankyou much
Frank 1953